Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 261862..262493 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag OQW59_RS04150 Protein ID WP_003837806.1
Coordinates 261862..262137 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag OQW59_RS04155 Protein ID WP_003837808.1
Coordinates 262134..262493 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS04140 (257913) 257913..260660 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
OQW59_RS04145 (260660) 260660..261784 + 1125 WP_003837801.1 ABC transporter permease -
OQW59_RS04150 (261862) 261862..262137 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
OQW59_RS04155 (262134) 262134..262493 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OQW59_RS04160 (262606) 262606..263007 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
OQW59_RS04165 (263057) 263057..263635 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
OQW59_RS04170 (263698) 263698..264747 - 1050 WP_003023393.1 AI-2E family transporter -
OQW59_RS04175 (264881) 264881..266098 + 1218 WP_032950436.1 MFS transporter -
OQW59_RS04180 (266102) 266102..266659 - 558 WP_003837816.1 DcrB family lipoprotein -
OQW59_RS04185 (266732) 266732..267397 - 666 WP_088169168.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T264465 WP_003837806.1 NZ_CP110894:261862-262137 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT264465 WP_003837808.1 NZ_CP110894:262134-262493 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References