Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1579..2133 Replicon plasmid pCF1807-5
Accession NZ_CP110893
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag OQW59_RS02805 Protein ID WP_061586429.1
Coordinates 1819..2133 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A6P1V7Y5
Locus tag OQW59_RS02800 Protein ID WP_025861853.1
Coordinates 1579..1815 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS02795 (OQW59_02790) 13..714 + 702 WP_254919869.1 RepA family replication protein -
OQW59_RS02800 (OQW59_02795) 1579..1815 + 237 WP_025861853.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OQW59_RS02805 (OQW59_02800) 1819..2133 + 315 WP_061586429.1 CcdB family protein Toxin
OQW59_RS02810 (OQW59_02805) 2444..2938 - 495 WP_223230020.1 DUF4326 domain-containing protein -
OQW59_RS02815 (OQW59_02810) 3007..3459 - 453 WP_151355700.1 DUF488 domain-containing protein -
OQW59_RS02820 (OQW59_02815) 3460..4107 - 648 WP_061586427.1 hypothetical protein -
OQW59_RS02825 (OQW59_02820) 4376..5023 + 648 WP_004178130.1 ParA family protein -
OQW59_RS02830 (OQW59_02825) 5064..5297 + 234 WP_004178129.1 hypothetical protein -
OQW59_RS02835 (OQW59_02830) 5335..5631 - 297 WP_223230019.1 hypothetical protein -
OQW59_RS02840 (OQW59_02835) 5737..6210 - 474 WP_061586426.1 thermonuclease family protein -
OQW59_RS02845 (OQW59_02840) 6247..7002 - 756 WP_023316386.1 MobC family replication-relaxation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..22675 22675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11484.40 Da        Isoelectric Point: 8.0227

>T264464 WP_061586429.1 NZ_CP110893:1819-2133 [Citrobacter freundii]
MQFTVYSNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLNDGKEYAVMTHEMASIPARSLG
AVFCDASLHRTQVKAAIDFLLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8907.84 Da        Isoelectric Point: 4.8040

>AT264464 WP_025861853.1 NZ_CP110893:1579-1815 [Citrobacter freundii]
MATTQRATQSVTMTVERALLSRAREAGINLSATLTAALDAELRQYEAKKWQEENNEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V7Y5

References