Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2251775..2252403 Replicon chromosome
Accession NZ_CP110888
Organism Thermoanaerobacter sp. RKWS2

Toxin (Protein)


Gene name mazF Uniprot ID B0KD57
Locus tag OEI98_RS11840 Protein ID WP_003867472.1
Coordinates 2251775..2252125 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M8DD10
Locus tag OEI98_RS11845 Protein ID WP_003870023.1
Coordinates 2252128..2252403 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEI98_RS11820 (OEI98_002364) 2247265..2248002 - 738 WP_003870018.1 WecB/TagA/CpsF family glycosyltransferase -
OEI98_RS11825 (OEI98_002365) 2248005..2249096 - 1092 WP_003870019.1 polysaccharide pyruvyl transferase CsaB -
OEI98_RS11830 (OEI98_002366) 2249098..2251110 - 2013 WP_019907959.1 DUF5693 family protein -
OEI98_RS11835 (OEI98_002367) 2251225..2251677 - 453 WP_003870021.1 hypothetical protein -
OEI98_RS11840 (OEI98_002368) 2251775..2252125 - 351 WP_003867472.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OEI98_RS11845 (OEI98_002369) 2252128..2252403 - 276 WP_003870023.1 ribbon-helix-helix protein, CopG family Antitoxin
OEI98_RS11850 (OEI98_002370) 2252505..2253659 - 1155 WP_003870024.1 alanine racemase -
OEI98_RS11855 (OEI98_002371) 2253679..2254695 - 1017 WP_244262740.1 outer membrane lipoprotein carrier protein LolA -
OEI98_RS11860 (OEI98_002372) 2254700..2256232 - 1533 WP_003870026.1 NAD(P)H-hydrate dehydratase -
OEI98_RS11865 (OEI98_002373) 2256195..2256611 - 417 WP_003870027.1 holo-ACP synthase -
OEI98_RS11870 (OEI98_002374) 2256707..2257072 - 366 WP_003867466.1 DUF6514 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12933.02 Da        Isoelectric Point: 6.4714

>T264457 WP_003867472.1 NZ_CP110888:c2252125-2251775 [Thermoanaerobacter sp. RKWS2]
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLNKDSVVLLEQI
RTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10547.32 Da        Isoelectric Point: 6.3662

>AT264457 WP_003870023.1 NZ_CP110888:c2252403-2252128 [Thermoanaerobacter sp. RKWS2]
VGETKRILVSLPQSLLEEVDVLAAMENRNRSEFIREAMKLYIRERKKVQIRESMKKGYLEMAAINSELAEMGLTAENECF
TGYEMKLKKCD

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B3BRL3

Antitoxin

Source ID Structure
AlphaFold DB M8DD10

References