264456

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4877075..4877670 Replicon chromosome
Accession NZ_CP110887
Organism Dickeya solani strain DsR207

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag OQ522_RS21230 Protein ID WP_013318177.1
Coordinates 4877075..4877452 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag OQ522_RS21235 Protein ID WP_022633800.1
Coordinates 4877449..4877670 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ522_RS21210 (OQ522_11965) 4872741..4873007 + 267 WP_022633797.1 hypothetical protein -
OQ522_RS21215 (OQ522_11970) 4873239..4873421 + 183 WP_072142890.1 hypothetical protein -
OQ522_RS21220 (OQ522_11975) 4873503..4875269 - 1767 WP_022633798.1 ATP-binding protein -
OQ522_RS21225 (OQ522_11980) 4875259..4876437 - 1179 WP_022633799.1 hypothetical protein -
OQ522_RS21230 (OQ522_11985) 4877075..4877452 - 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OQ522_RS21235 (OQ522_11990) 4877449..4877670 - 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQ522_RS21240 (OQ522_11995) 4877811..4878959 - 1149 WP_022633801.1 L-threonine dehydrogenase -
OQ522_RS21245 (OQ522_12000) 4879346..4879801 + 456 WP_022633802.1 NUDIX domain-containing protein -
OQ522_RS21250 (OQ522_12005) 4879873..4880550 - 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
OQ522_RS21255 (OQ522_12010) 4880550..4881269 - 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4868631..4877670 9039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T264456 WP_013318177.1 NZ_CP110887:c4877452-4877075 [Dickeya solani]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT264456 WP_022633800.1 NZ_CP110887:c4877670-4877449 [Dickeya solani]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References