264449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3927751..3928368 Replicon chromosome
Accession NZ_CP110887
Organism Dickeya solani strain DsR207

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag OQ522_RS17115 Protein ID WP_012764944.1
Coordinates 3928189..3928368 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag OQ522_RS17110 Protein ID WP_022633005.1
Coordinates 3927751..3928161 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ522_RS17085 (OQ522_07845) 3923251..3924168 + 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -
OQ522_RS17090 (OQ522_07850) 3924165..3925187 + 1023 WP_022633001.1 iron ABC transporter permease -
OQ522_RS17095 (OQ522_07855) 3925180..3926229 + 1050 WP_022633002.1 iron ABC transporter permease -
OQ522_RS17100 (OQ522_07860) 3926241..3927086 + 846 WP_023637730.1 ABC transporter ATP-binding protein -
OQ522_RS17105 (OQ522_07865) 3927083..3927748 + 666 WP_022633004.1 RraA family protein -
OQ522_RS17110 (OQ522_07870) 3927751..3928161 - 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OQ522_RS17115 (OQ522_07875) 3928189..3928368 - 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
OQ522_RS17120 (OQ522_07880) 3928690..3929052 + 363 WP_071598627.1 hypothetical protein -
OQ522_RS17125 (OQ522_07885) 3929388..3930443 - 1056 WP_022633006.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T264449 WP_012764944.1 NZ_CP110887:c3928368-3928189 [Dickeya solani]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT264449 WP_022633005.1 NZ_CP110887:c3928161-3927751 [Dickeya solani]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References