Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2758440..2758966 Replicon chromosome
Accession NZ_CP110887
Organism Dickeya solani strain DsR207

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag OQ522_RS12040 Protein ID WP_022632051.1
Coordinates 2758440..2758745 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag OQ522_RS12045 Protein ID WP_022632052.1
Coordinates 2758748..2758966 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ522_RS12020 (OQ522_02775) 2753656..2754053 + 398 Protein_2327 DUF3577 domain-containing protein -
OQ522_RS12025 (OQ522_02780) 2754169..2755440 + 1272 WP_022632048.1 hypothetical protein -
OQ522_RS12030 (OQ522_02785) 2755444..2756022 + 579 WP_023637591.1 hypothetical protein -
OQ522_RS12035 (OQ522_02790) 2756010..2757950 + 1941 WP_022632050.1 hypothetical protein -
OQ522_RS12040 (OQ522_02795) 2758440..2758745 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
OQ522_RS12045 (OQ522_02800) 2758748..2758966 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
OQ522_RS12050 (OQ522_02805) 2759025..2759768 - 744 WP_022632053.1 MobC family replication-relaxation protein -
OQ522_RS12055 (OQ522_02810) 2760671..2761021 - 351 WP_013316250.1 hypothetical protein -
OQ522_RS12060 (OQ522_02815) 2761144..2761332 + 189 WP_033111580.1 hypothetical protein -
OQ522_RS12065 (OQ522_02820) 2761472..2762731 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
OQ522_RS12075 (OQ522_02830) 2763129..2763704 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2752577..2762908 10331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T264445 WP_022632051.1 NZ_CP110887:c2758745-2758440 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT264445 WP_022632052.1 NZ_CP110887:c2758966-2758748 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References