Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2154074..2155662 Replicon chromosome
Accession NZ_CP110887
Organism Dickeya solani strain DsR207

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8W078
Locus tag OQ522_RS09225 Protein ID WP_022635525.1
Coordinates 2154343..2155662 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2K8W0B1
Locus tag OQ522_RS09220 Protein ID WP_022635524.1
Coordinates 2154074..2154343 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ522_RS09195 (OQ522_21360) 2149392..2150003 - 612 WP_022635519.1 NAD(P)-dependent oxidoreductase -
OQ522_RS09200 (OQ522_21365) 2150145..2150531 + 387 WP_022635520.1 helix-turn-helix domain-containing protein -
OQ522_RS09205 (OQ522_21370) 2150630..2151715 - 1086 WP_022635521.1 4-hydroxyphenylpyruvate dioxygenase -
OQ522_RS09210 (OQ522_21375) 2152030..2152803 + 774 WP_022635522.1 MBL fold metallo-hydrolase -
OQ522_RS09215 (OQ522_21380) 2152847..2153803 + 957 WP_026595316.1 helix-turn-helix domain-containing protein -
OQ522_RS09220 (OQ522_21385) 2154074..2154343 + 270 WP_022635524.1 helix-turn-helix domain-containing protein Antitoxin
OQ522_RS09225 (OQ522_21390) 2154343..2155662 + 1320 WP_022635525.1 type II toxin-antitoxin system HipA family toxin Toxin
OQ522_RS09230 (OQ522_21395) 2155734..2157098 - 1365 WP_022635526.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
OQ522_RS09235 (OQ522_21400) 2157214..2158845 - 1632 WP_022635527.1 membrane protein insertase YidC -
OQ522_RS09240 (OQ522_21405) 2158848..2159105 - 258 WP_071598660.1 membrane protein insertion efficiency factor YidD -
OQ522_RS09245 (OQ522_21410) 2159069..2159428 - 360 WP_022635528.1 ribonuclease P protein component -
OQ522_RS09250 (OQ522_21415) 2159447..2159587 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49161.32 Da        Isoelectric Point: 6.6616

>T264443 WP_022635525.1 NZ_CP110887:2154343-2155662 [Dickeya solani]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE

Download         Length: 1320 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9950.26 Da        Isoelectric Point: 10.0983

>AT264443 WP_022635524.1 NZ_CP110887:2154074-2154343 [Dickeya solani]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W078

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W0B1

References