264441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4877135..4877730 Replicon chromosome
Accession NZ_CP110886
Organism Dickeya solani strain DsR34

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag OQ520_RS21230 Protein ID WP_013318177.1
Coordinates 4877135..4877512 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag OQ520_RS21235 Protein ID WP_022633800.1
Coordinates 4877509..4877730 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ520_RS21210 (OQ520_11965) 4872801..4873067 + 267 WP_022633797.1 hypothetical protein -
OQ520_RS21215 (OQ520_11970) 4873299..4873481 + 183 WP_072142890.1 hypothetical protein -
OQ520_RS21220 (OQ520_11975) 4873563..4875329 - 1767 WP_022633798.1 ATP-binding protein -
OQ520_RS21225 (OQ520_11980) 4875319..4876497 - 1179 WP_022633799.1 hypothetical protein -
OQ520_RS21230 (OQ520_11985) 4877135..4877512 - 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OQ520_RS21235 (OQ520_11990) 4877509..4877730 - 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQ520_RS21240 (OQ520_11995) 4877871..4879019 - 1149 WP_022633801.1 L-threonine dehydrogenase -
OQ520_RS21245 (OQ520_12000) 4879406..4879861 + 456 WP_022633802.1 NUDIX domain-containing protein -
OQ520_RS21250 (OQ520_12005) 4879933..4880610 - 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
OQ520_RS21255 (OQ520_12010) 4880610..4881329 - 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4868691..4877730 9039
- inside Prophage - - 4863357..4918696 55339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T264441 WP_013318177.1 NZ_CP110886:c4877512-4877135 [Dickeya solani]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT264441 WP_022633800.1 NZ_CP110886:c4877730-4877509 [Dickeya solani]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References