Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4877135..4877730 Replicon chromosome
Accession NZ_CP110886
Organism Dickeya solani strain DsR34

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag OQ520_RS21230 Protein ID WP_013318177.1
Coordinates 4877135..4877512 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag OQ520_RS21235 Protein ID WP_022633800.1
Coordinates 4877509..4877730 (-) Length 74 a.a.

Genomic Context

OQ520_RS21210OQ520_RS21215OQ520_RS21245OQ520_RS21220OQ520_RS21225OQ520_RS21230OQ520_RS21235OQ520_RS21240OQ520_RS21250OQ520_RS21255
Location: 4872801..4873067 (267 bp)
Type: Others
Protein ID: WP_022633797.1
Location: 4873299..4873481 (183 bp)
Type: Others
Protein ID: WP_072142890.1
Location: 4879406..4879861 (456 bp)
Type: Others
Protein ID: WP_022633802.1
Location: 4873563..4875329 (1767 bp)
Type: Others
Protein ID: WP_022633798.1
Location: 4875319..4876497 (1179 bp)
Type: Others
Protein ID: WP_022633799.1
Location: 4877135..4877512 (378 bp)
Type: Toxin
Protein ID: WP_013318177.1
Location: 4877509..4877730 (222 bp)
Type: Antitoxin
Protein ID: WP_022633800.1
Location: 4877871..4879019 (1149 bp)
Type: Others
Protein ID: WP_022633801.1
Location: 4879933..4880610 (678 bp)
Type: Others
Protein ID: WP_022633803.1
Location: 4880610..4881329 (720 bp)
Type: Others
Protein ID: WP_022633804.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OQ520_RS21210 (OQ520_11965)4872801..4873067+267WP_022633797.1hypothetical protein-
OQ520_RS21215 (OQ520_11970)4873299..4873481+183WP_072142890.1hypothetical protein-
OQ520_RS21220 (OQ520_11975)4873563..4875329-1767WP_022633798.1ATP-binding protein-
OQ520_RS21225 (OQ520_11980)4875319..4876497-1179WP_022633799.1hypothetical protein-
OQ520_RS21230 (OQ520_11985)4877135..4877512-378WP_013318177.1type II toxin-antitoxin system death-on-curing family toxinToxin
OQ520_RS21235 (OQ520_11990)4877509..4877730-222WP_022633800.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
OQ520_RS21240 (OQ520_11995)4877871..4879019-1149WP_022633801.1L-threonine dehydrogenase-
OQ520_RS21245 (OQ520_12000)4879406..4879861+456WP_022633802.1NUDIX domain-containing protein-
OQ520_RS21250 (OQ520_12005)4879933..4880610-678WP_022633803.1respiratory nitrate reductase subunit gamma-
OQ520_RS21255 (OQ520_12010)4880610..4881329-720WP_022633804.1nitrate reductase molybdenum cofactor assembly chaperone-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--4868691..48777309039
-insideProphage--4863357..491869655339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T264441 WP_013318177.1 NZ_CP110886:c4877512-4877135 [Dickeya solani]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT264441 WP_022633800.1 NZ_CP110886:c4877730-4877509 [Dickeya solani]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBE0SEA8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2K8VUJ6

References