Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4042583..4043136 Replicon chromosome
Accession NZ_CP110886
Organism Dickeya solani strain DsR34

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag OQ520_RS17620 Protein ID WP_022633101.1
Coordinates 4042822..4043136 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W593
Locus tag OQ520_RS17615 Protein ID WP_022633100.1
Coordinates 4042583..4042819 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ520_RS17595 (OQ520_08350) 4038159..4039808 + 1650 WP_022633097.1 response regulator receiver domain -
OQ520_RS17600 (OQ520_08355) 4040169..4040570 - 402 WP_023637748.1 hypothetical protein -
OQ520_RS17605 (OQ520_08360) 4040634..4040927 - 294 WP_146053334.1 hypothetical protein -
OQ520_RS17610 (OQ520_08365) 4041318..4042262 + 945 WP_022633099.1 zincin-like metallopeptidase domain-containing protein -
OQ520_RS17615 (OQ520_08370) 4042583..4042819 + 237 WP_022633100.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OQ520_RS17620 (OQ520_08375) 4042822..4043136 + 315 WP_022633101.1 CcdB family protein Toxin
OQ520_RS17625 (OQ520_08380) 4043250..4043339 - 90 Protein_3424 mobilization protein mobC -
OQ520_RS17630 (OQ520_08385) 4043566..4044876 - 1311 WP_223849471.1 type II toxin-antitoxin system HipA family toxin -
OQ520_RS17635 (OQ520_08390) 4044873..4045280 - 408 WP_071598628.1 helix-turn-helix transcriptional regulator -
OQ520_RS17640 (OQ520_08395) 4045663..4046409 - 747 WP_022633104.1 MobC family replication-relaxation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp 4033600..4081978 48378


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11459.38 Da        Isoelectric Point: 7.9859

>T264435 WP_022633101.1 NZ_CP110886:4042822-4043136 [Dickeya solani]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9020.06 Da        Isoelectric Point: 6.2206

>AT264435 WP_022633100.1 NZ_CP110886:4042583-4042819 [Dickeya solani]
MTAKQRNTQSVTMTVERALLVRAREAGINLSAILTTALDAELRHHEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W593

References