Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3927806..3928423 Replicon chromosome
Accession NZ_CP110886
Organism Dickeya solani strain DsR34

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag OQ520_RS17115 Protein ID WP_012764944.1
Coordinates 3928244..3928423 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag OQ520_RS17110 Protein ID WP_022633005.1
Coordinates 3927806..3928216 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ520_RS17085 (OQ520_07845) 3923306..3924223 + 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -
OQ520_RS17090 (OQ520_07850) 3924220..3925242 + 1023 WP_022633001.1 iron ABC transporter permease -
OQ520_RS17095 (OQ520_07855) 3925235..3926284 + 1050 WP_022633002.1 iron ABC transporter permease -
OQ520_RS17100 (OQ520_07860) 3926296..3927141 + 846 WP_023637730.1 ABC transporter ATP-binding protein -
OQ520_RS17105 (OQ520_07865) 3927138..3927803 + 666 WP_022633004.1 RraA family protein -
OQ520_RS17110 (OQ520_07870) 3927806..3928216 - 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OQ520_RS17115 (OQ520_07875) 3928244..3928423 - 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
OQ520_RS17120 (OQ520_07880) 3928745..3929107 + 363 WP_071598627.1 hypothetical protein -
OQ520_RS17125 (OQ520_07885) 3929443..3930498 - 1056 WP_022633006.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T264434 WP_012764944.1 NZ_CP110886:c3928423-3928244 [Dickeya solani]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT264434 WP_022633005.1 NZ_CP110886:c3928216-3927806 [Dickeya solani]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References