264430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2758495..2759021 Replicon chromosome
Accession NZ_CP110886
Organism Dickeya solani strain DsR34

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag OQ520_RS12040 Protein ID WP_022632051.1
Coordinates 2758495..2758800 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag OQ520_RS12045 Protein ID WP_022632052.1
Coordinates 2758803..2759021 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ520_RS12020 (OQ520_02775) 2753711..2754108 + 398 Protein_2327 DUF3577 domain-containing protein -
OQ520_RS12025 (OQ520_02780) 2754224..2755495 + 1272 WP_022632048.1 hypothetical protein -
OQ520_RS12030 (OQ520_02785) 2755499..2756077 + 579 WP_023637591.1 hypothetical protein -
OQ520_RS12035 (OQ520_02790) 2756065..2758005 + 1941 WP_022632050.1 hypothetical protein -
OQ520_RS12040 (OQ520_02795) 2758495..2758800 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
OQ520_RS12045 (OQ520_02800) 2758803..2759021 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
OQ520_RS12050 (OQ520_02805) 2759080..2759823 - 744 WP_022632053.1 MobC family replication-relaxation protein -
OQ520_RS12055 (OQ520_02810) 2760726..2761076 - 351 WP_013316250.1 hypothetical protein -
OQ520_RS12060 (OQ520_02815) 2761199..2761387 + 189 WP_033111580.1 hypothetical protein -
OQ520_RS12065 (OQ520_02820) 2761527..2762786 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
OQ520_RS12075 (OQ520_02830) 2763184..2763759 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2752632..2762963 10331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T264430 WP_022632051.1 NZ_CP110886:c2758800-2758495 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT264430 WP_022632052.1 NZ_CP110886:c2759021-2758803 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References