264428

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2154129..2155717 Replicon chromosome
Accession NZ_CP110886
Organism Dickeya solani strain DsR34

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8W078
Locus tag OQ520_RS09225 Protein ID WP_022635525.1
Coordinates 2154398..2155717 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2K8W0B1
Locus tag OQ520_RS09220 Protein ID WP_022635524.1
Coordinates 2154129..2154398 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ520_RS09195 (OQ520_21360) 2149447..2150058 - 612 WP_022635519.1 NAD(P)-dependent oxidoreductase -
OQ520_RS09200 (OQ520_21365) 2150200..2150586 + 387 WP_022635520.1 helix-turn-helix domain-containing protein -
OQ520_RS09205 (OQ520_21370) 2150685..2151770 - 1086 WP_022635521.1 4-hydroxyphenylpyruvate dioxygenase -
OQ520_RS09210 (OQ520_21375) 2152085..2152858 + 774 WP_022635522.1 MBL fold metallo-hydrolase -
OQ520_RS09215 (OQ520_21380) 2152902..2153858 + 957 WP_026595316.1 helix-turn-helix domain-containing protein -
OQ520_RS09220 (OQ520_21385) 2154129..2154398 + 270 WP_022635524.1 helix-turn-helix domain-containing protein Antitoxin
OQ520_RS09225 (OQ520_21390) 2154398..2155717 + 1320 WP_022635525.1 type II toxin-antitoxin system HipA family toxin Toxin
OQ520_RS09230 (OQ520_21395) 2155789..2157153 - 1365 WP_022635526.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
OQ520_RS09235 (OQ520_21400) 2157269..2158900 - 1632 WP_022635527.1 membrane protein insertase YidC -
OQ520_RS09240 (OQ520_21405) 2158903..2159160 - 258 WP_071598660.1 membrane protein insertion efficiency factor YidD -
OQ520_RS09245 (OQ520_21410) 2159124..2159483 - 360 WP_022635528.1 ribonuclease P protein component -
OQ520_RS09250 (OQ520_21415) 2159502..2159642 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49161.32 Da        Isoelectric Point: 6.6616

>T264428 WP_022635525.1 NZ_CP110886:2154398-2155717 [Dickeya solani]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE

Download         Length: 1320 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9950.26 Da        Isoelectric Point: 10.0983

>AT264428 WP_022635524.1 NZ_CP110886:2154129-2154398 [Dickeya solani]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W078

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W0B1

References