Detailed information of TA system TA264427

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1005200..1007040
• Replicon: chromosome
• Accession: NZ_CP110886
• Organism: Dickeya solani strain DsR34

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2K8VX87
• Locus tag: OQ520_RS04355
• Protein ID: WP_022634631.1
• Coordinates: 1005694..1007040 (-)
• Length: 449 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: OQ520_RS04350
• Protein ID: WP_022634630.1
• Coordinates: 1005200..1005697 (-)
• Length: 166 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OQ520_RS04325 (OQ520_16490)	1000517..1001356	-	840	WP_022634625.1	MurR/RpiR family transcriptional regulator	-
OQ520_RS04330 (OQ520_16495)	1001531..1003120	+	1590	WP_022634626.1	gamma-glutamyltransferase family protein	-
OQ520_RS04335 (OQ520_16500)	1003165..1003362	+	198	WP_022634627.1	oxalurate catabolism protein HpxX	-
OQ520_RS04340 (OQ520_16505)	1003359..1004771	+	1413	WP_022634628.1	AtzE family amidohydrolase	-
OQ520_RS04345 (OQ520_16510)	1004768..1005148	+	381	WP_022634629.1	oxalurate catabolism protein HpxZ	-
OQ520_RS04350 (OQ520_16515)	1005200..1005697	-	498	WP_022634630.1	helix-turn-helix transcriptional regulator	Antitoxin
OQ520_RS04355 (OQ520_16520)	1005694..1007040	-	1347	WP_022634631.1	HipA domain-containing protein	Toxin
OQ520_RS04360 (OQ520_16525)	1007313..1008260	-	948	WP_022634632.1	allantoinase PuuE	-
OQ520_RS04365 (OQ520_16530)	1008304..1009041	-	738	WP_022634633.1	allantoin racemase	-
OQ520_RS04370 (OQ520_16535)	1009038..1009781	-	744	WP_022634634.1	GntR family transcriptional regulator	-
OQ520_RS04375 (OQ520_16540)	1009934..1011418	+	1485	WP_022634635.1	NCS1 family nucleobase:cation symporter-1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (165-392)

Antitoxin

• Cro/C1-type helix-turn-helix domain (89-142)

Sequences

Toxin

Protein

• Length: 449 a.a.
• Molecular weight: 50541.28 Da
• Isoelectric Point: 4.9663

>T264427 WP_022634631.1 NZ_CP110886:c1007040-1005694 [Dickeya solani]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Nucleotide

• Length: 1347 bp

Antitoxin

Protein

• Length: 166 a.a.
• Molecular weight: 18174.98 Da
• Isoelectric Point: 10.6920

>AT264427 WP_022634630.1 NZ_CP110886:c1005697-1005200 [Dickeya solani]
MSQKRNNTTDVYAGADDVQETIRKLRQRVQERNVALEQMLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRR
MMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTLSEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILAT
APASR

Nucleotide

• Length: 498 bp

Structures

Toxin

• AlphaFold DB: A0A2K8VX87