Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3877740..3878401 Replicon chromosome
Accession NZ_CP110873
Organism Enterobacter kobei strain SCLZS19

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag OQE50_RS18735 Protein ID WP_248188259.1
Coordinates 3877740..3878063 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A241Q747
Locus tag OQE50_RS18740 Protein ID WP_048997880.1
Coordinates 3878084..3878401 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQE50_RS18715 (3873288) 3873288..3875039 - 1752 WP_179121184.1 arsenite efflux transporter ATPase subunit ArsA -
OQE50_RS18720 (3875057) 3875057..3875419 - 363 WP_014885111.1 arsenite efflux transporter metallochaperone ArsD -
OQE50_RS18725 (3875469) 3875469..3875822 - 354 WP_269195172.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
OQE50_RS18730 (3876648) 3876648..3876968 + 321 WP_228037291.1 YecR family lipoprotein -
OQE50_RS18735 (3877740) 3877740..3878063 - 324 WP_248188259.1 TA system toxin CbtA family protein Toxin
OQE50_RS18740 (3878084) 3878084..3878401 - 318 WP_048997880.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OQE50_RS18745 (3878420) 3878420..3878641 - 222 WP_048997881.1 DUF987 domain-containing protein -
OQE50_RS18750 (3878650) 3878650..3879126 - 477 WP_049016517.1 RadC family protein -
OQE50_RS18755 (3879142) 3879142..3879531 - 390 Protein_3666 antirestriction protein -
OQE50_RS18760 (3879521) 3879521..3879682 - 162 Protein_3667 ArsB/NhaD family transporter -
OQE50_RS18765 (3879730) 3879730..3881481 - 1752 WP_248188260.1 arsenical pump-driving ATPase -
OQE50_RS18770 (3881498) 3881498..3881860 - 363 WP_046449097.1 arsenite efflux transporter metallochaperone ArsD -
OQE50_RS18775 (3881908) 3881908..3882258 - 351 WP_248188261.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3876316..3887806 11490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12412.29 Da        Isoelectric Point: 5.6981

>T264421 WP_248188259.1 NZ_CP110873:c3878063-3877740 [Enterobacter kobei]
MKSQPATTQRAAKPCLSPVDVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARLDLGLLNRN

Download         Length: 324 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11993.64 Da        Isoelectric Point: 7.6976

>AT264421 WP_048997880.1 NZ_CP110873:c3878401-3878084 [Enterobacter kobei]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGQFSDAECRKLDVAFPYFIRQMESMLTTGELNPRHTHCVTLYR
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A241Q747

References