Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1739593..1740390 Replicon chromosome
Accession NZ_CP110873
Organism Enterobacter kobei strain SCLZS19

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OQE50_RS08385 Protein ID WP_176450254.1
Coordinates 1739866..1740390 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A2W0G3H3
Locus tag OQE50_RS08380 Protein ID WP_014883303.1
Coordinates 1739593..1739862 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQE50_RS08350 (1735213) 1735213..1735713 + 501 WP_014883299.1 DedA family protein -
OQE50_RS08355 (1735817) 1735817..1737058 + 1242 WP_023337066.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
OQE50_RS08360 (1737093) 1737093..1737320 - 228 WP_014883300.1 YccJ family protein -
OQE50_RS08365 (1737339) 1737339..1737935 - 597 WP_014883301.1 NAD(P)H:quinone oxidoreductase -
OQE50_RS08370 (1738327) 1738327..1738497 + 171 WP_023332656.1 general stress protein -
OQE50_RS08375 (1738614) 1738614..1739531 + 918 WP_047028038.1 DMT family transporter -
OQE50_RS08380 (1739593) 1739593..1739862 + 270 WP_014883303.1 DUF1778 domain-containing protein Antitoxin
OQE50_RS08385 (1739866) 1739866..1740390 + 525 WP_176450254.1 GNAT family N-acetyltransferase Toxin
OQE50_RS08390 (1740464) 1740464..1741786 - 1323 WP_014883305.1 pyrimidine utilization transport protein G -
OQE50_RS08395 (1741808) 1741808..1742302 - 495 WP_023332659.1 pyrimidine utilization flavin reductase protein F -
OQE50_RS08400 (1742312) 1742312..1742902 - 591 WP_193970071.1 malonic semialdehyde reductase -
OQE50_RS08405 (1742912) 1742912..1743712 - 801 WP_193970070.1 pyrimidine utilization protein D -
OQE50_RS08410 (1743720) 1743720..1744106 - 387 WP_014883309.1 pyrimidine utilization protein C -
OQE50_RS08415 (1744118) 1744118..1744807 - 690 WP_193970069.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19689.59 Da        Isoelectric Point: 8.9464

>T264416 WP_176450254.1 NZ_CP110873:1739866-1740390 [Enterobacter kobei]
IVANLTIEMFSEGSDYDFRGFDCGEPSLNAFLTEHLVRQHKGRILRGYLLKDRDHPRVLGYYTLSGSCFEKAMLPSKTQQ
RRIPYVNVPSVTLGRLAVHKDLQGKEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNEQAKRFYLKQGFIPLTGENSHSL
FFPTKSIEQLFEQA

Download         Length: 525 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10278.72 Da        Isoelectric Point: 5.8836

>AT264416 WP_014883303.1 NZ_CP110873:1739593-1739862 [Enterobacter kobei]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNESSWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0G3H3

References