Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 980699..981378 Replicon chromosome
Accession NZ_CP110873
Organism Enterobacter kobei strain SCLZS19

Toxin (Protein)


Gene name ykfI Uniprot ID A0A8B3US07
Locus tag OQE50_RS04690 Protein ID WP_007777710.1
Coordinates 980699..981040 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8B3USS8
Locus tag OQE50_RS04695 Protein ID WP_007777712.1
Coordinates 981061..981378 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQE50_RS04665 (975883) 975883..976284 + 402 WP_014882682.1 sigma factor-binding protein Crl -
OQE50_RS04670 (976398) 976398..977450 - 1053 WP_063944063.1 phosphoporin PhoE -
OQE50_RS04675 (977756) 977756..978859 + 1104 WP_014882684.1 glutamate 5-kinase -
OQE50_RS04680 (978871) 978871..980124 + 1254 WP_014882685.1 glutamate-5-semialdehyde dehydrogenase -
OQE50_RS04690 (980699) 980699..981040 - 342 WP_007777710.1 TA system toxin CbtA family protein Toxin
OQE50_RS04695 (981061) 981061..981378 - 318 WP_007777712.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OQE50_RS04700 (981445) 981445..982142 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
OQE50_RS04705 (982158) 982158..982712 - 555 Protein_911 hypothetical protein -
OQE50_RS04710 (983085) 983085..983324 + 240 WP_014882702.1 hypothetical protein -
OQE50_RS04715 (983357) 983357..983736 + 380 Protein_913 DUF3387 domain-containing protein -
OQE50_RS04720 (983803) 983803..984270 - 468 WP_014882704.1 GNAT family N-acetyltransferase -
OQE50_RS04725 (984567) 984567..985337 - 771 WP_179120549.1 class I SAM-dependent methyltransferase -
OQE50_RS04730 (985348) 985348..985605 - 258 WP_014882706.1 YjhX family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12934.88 Da        Isoelectric Point: 8.0308

>T264414 WP_007777710.1 NZ_CP110873:c981040-980699 [Enterobacter kobei]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLQAVDILRARQATGLLQQSRSNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12005.67 Da        Isoelectric Point: 7.3723

>AT264414 WP_007777712.1 NZ_CP110873:c981378-981061 [Enterobacter kobei]
MTHITWGLQRNITPRLGARLVQEGNRLHYLADRASITGKFSDTECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVIMYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3US07

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3USS8

References