Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 588025..588728 Replicon chromosome
Accession NZ_CP110873
Organism Enterobacter kobei strain SCLZS19

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag OQE50_RS02860 Protein ID WP_040196446.1
Coordinates 588387..588728 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag OQE50_RS02855 Protein ID WP_044864456.1
Coordinates 588025..588366 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQE50_RS02820 (583179) 583179..584054 + 876 WP_044864450.1 GTPase family protein -
OQE50_RS02825 (584298) 584298..585014 + 717 WP_044864451.1 WYL domain-containing protein -
OQE50_RS02830 (585050) 585050..585502 + 453 WP_160387433.1 hypothetical protein -
OQE50_RS02835 (585574) 585574..586047 + 474 WP_044864453.1 hypothetical protein -
OQE50_RS02840 (586167) 586167..586988 + 822 WP_023329299.1 DUF932 domain-containing protein -
OQE50_RS02845 (587019) 587019..587459 + 441 WP_023329298.1 antirestriction protein -
OQE50_RS02850 (587472) 587472..588014 + 543 WP_044864455.1 DNA repair protein RadC -
OQE50_RS02855 (588025) 588025..588366 + 342 WP_044864456.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OQE50_RS02860 (588387) 588387..588728 + 342 WP_040196446.1 TA system toxin CbtA family protein Toxin
OQE50_RS02865 (588987) 588987..589994 + 1008 WP_044864458.1 restriction endonuclease -
OQE50_RS02870 (590363) 590363..591664 + 1302 WP_193970453.1 tyrosine-type recombinase/integrase -
OQE50_RS02875 (591791) 591791..592771 + 981 WP_266072557.1 DNA phosphorothioation-dependent restriction protein DptF -
OQE50_RS02880 (592706) 592706..593686 - 981 WP_000082736.1 IS5-like element ISEc68 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn fosA - 592706..595416 2710
- inside Prophage fosA - 553634..595416 41782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12791.74 Da        Isoelectric Point: 7.1648

>T264413 WP_040196446.1 NZ_CP110873:588387-588728 [Enterobacter kobei]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12843.36 Da        Isoelectric Point: 5.4792

>AT264413 WP_044864456.1 NZ_CP110873:588025-588366 [Enterobacter kobei]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLIDRASITGDFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References