Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3891307..3891902 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag OQ464_RS19105 Protein ID WP_000239577.1
Coordinates 3891307..3891657 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag OQ464_RS19110 Protein ID WP_001223208.1
Coordinates 3891651..3891902 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS19085 (3887644) 3887644..3887775 - 132 Protein_3726 ABC transporter permease -
OQ464_RS19090 (3887789) 3887789..3889291 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
OQ464_RS19095 (3889431) 3889431..3890387 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
OQ464_RS19100 (3890697) 3890697..3891227 + 531 WP_000055075.1 inorganic diphosphatase -
OQ464_RS19105 (3891307) 3891307..3891657 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
OQ464_RS19110 (3891651) 3891651..3891902 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OQ464_RS19115 (3892114) 3892114..3892455 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OQ464_RS19120 (3892458) 3892458..3896237 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T264407 WP_000239577.1 NZ_CP110859:c3891657-3891307 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT264407 WP_001223208.1 NZ_CP110859:c3891902-3891651 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References