Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3804850..3805664 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OQ464_RS18665 Protein ID WP_001054376.1
Coordinates 3804850..3805107 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OQ464_RS18670 Protein ID WP_001309181.1
Coordinates 3805119..3805664 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS18640 (3800138) 3800138..3801244 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
OQ464_RS18645 (3801309) 3801309..3802289 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OQ464_RS18650 (3802399) 3802399..3802604 + 206 Protein_3640 HNH endonuclease -
OQ464_RS18655 (3802872) 3802872..3804112 - 1241 Protein_3641 helicase YjhR -
OQ464_RS18660 (3804228) 3804228..3804359 + 132 WP_001309182.1 hypothetical protein -
OQ464_RS18665 (3804850) 3804850..3805107 + 258 WP_001054376.1 YjhX family toxin Toxin
OQ464_RS18670 (3805119) 3805119..3805664 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
OQ464_RS18675 (3805720) 3805720..3806466 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
OQ464_RS18680 (3806635) 3806635..3806853 + 219 Protein_3646 hypothetical protein -
OQ464_RS18685 (3806891) 3806891..3807007 + 117 Protein_3647 VOC family protein -
OQ464_RS18690 (3807252) 3807252..3808373 + 1122 WP_000010829.1 M42 family metallopeptidase -
OQ464_RS18695 (3808370) 3808370..3808648 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OQ464_RS18700 (3808660) 3808660..3809973 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3790047..3813888 23841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T264406 WP_001054376.1 NZ_CP110859:3804850-3805107 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT264406 WP_001309181.1 NZ_CP110859:3805119-3805664 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References