Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3333334..3333952 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag OQ464_RS16290 Protein ID WP_001290581.1
Coordinates 3333734..3333952 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OQ464_RS16285 Protein ID WP_000344800.1
Coordinates 3333334..3333708 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS16275 (3328423) 3328423..3329616 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OQ464_RS16280 (3329639) 3329639..3332788 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OQ464_RS16285 (3333334) 3333334..3333708 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OQ464_RS16290 (3333734) 3333734..3333952 + 219 WP_001290581.1 HHA domain-containing protein Toxin
OQ464_RS16295 (3334124) 3334124..3334675 + 552 WP_000102564.1 maltose O-acetyltransferase -
OQ464_RS16300 (3334791) 3334791..3335261 + 471 WP_000136192.1 YlaC family protein -
OQ464_RS16305 (3335425) 3335425..3336975 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OQ464_RS16310 (3337017) 3337017..3337370 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OQ464_RS16320 (3337749) 3337749..3338060 + 312 WP_000409911.1 MGMT family protein -
OQ464_RS16325 (3338091) 3338091..3338663 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T264402 WP_001290581.1 NZ_CP110859:3333734-3333952 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT264402 WP_000344800.1 NZ_CP110859:3333334-3333708 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References