Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2380574..2381212 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OQ464_RS11555 Protein ID WP_000813794.1
Coordinates 2381036..2381212 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OQ464_RS11550 Protein ID WP_001270286.1
Coordinates 2380574..2380990 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS11530 (2375726) 2375726..2376667 - 942 WP_001251304.1 ABC transporter permease -
OQ464_RS11535 (2376668) 2376668..2377681 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OQ464_RS11540 (2377699) 2377699..2378844 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
OQ464_RS11545 (2379089) 2379089..2380495 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
OQ464_RS11550 (2380574) 2380574..2380990 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OQ464_RS11555 (2381036) 2381036..2381212 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OQ464_RS11560 (2381434) 2381434..2381664 + 231 WP_000494244.1 YncJ family protein -
OQ464_RS11565 (2381756) 2381756..2383717 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OQ464_RS11570 (2383790) 2383790..2384326 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OQ464_RS11575 (2384418) 2384418..2385593 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T264401 WP_000813794.1 NZ_CP110859:c2381212-2381036 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT264401 WP_001270286.1 NZ_CP110859:c2380990-2380574 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References