Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846375..847029 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OQ464_RS04120 Protein ID WP_000244777.1
Coordinates 846622..847029 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OQ464_RS04115 Protein ID WP_000354046.1
Coordinates 846375..846641 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS04090 (841544) 841544..842287 + 744 WP_000951964.1 SDR family oxidoreductase -
OQ464_RS04095 (842344) 842344..843777 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
OQ464_RS04100 (843822) 843822..844133 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
OQ464_RS04105 (844297) 844297..844956 + 660 WP_000250274.1 hemolysin III family protein -
OQ464_RS04110 (845152) 845152..846132 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
OQ464_RS04115 (846375) 846375..846641 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OQ464_RS04120 (846622) 846622..847029 + 408 WP_000244777.1 protein YgfX Toxin
OQ464_RS04125 (847069) 847069..847590 - 522 WP_001055874.1 flavodoxin FldB -
OQ464_RS04130 (847702) 847702..848598 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OQ464_RS04135 (848623) 848623..849333 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OQ464_RS04140 (849339) 849339..851072 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T264389 WP_000244777.1 NZ_CP110859:846622-847029 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT264389 WP_000354046.1 NZ_CP110859:846375-846641 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References