Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4779605..4780221 Replicon chromosome
Accession NZ_CP110857
Organism Enterobacter hormaechei strain K432

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OQO37_RS23255 Protein ID WP_015569913.1
Coordinates 4779605..4779976 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag OQO37_RS23260 Protein ID WP_015569912.1
Coordinates 4779979..4780221 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQO37_RS23240 (OQO37_23240) 4777105..4778007 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
OQO37_RS23245 (OQO37_23245) 4778004..4778639 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
OQO37_RS23250 (OQO37_23250) 4778636..4779565 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
OQO37_RS23255 (OQO37_23255) 4779605..4779976 - 372 WP_015569913.1 PIN domain-containing protein Toxin
OQO37_RS23260 (OQO37_23260) 4779979..4780221 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
OQO37_RS23265 (OQO37_23265) 4780420..4781340 + 921 WP_015569911.1 alpha/beta hydrolase -
OQO37_RS23270 (OQO37_23270) 4781349..4782290 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
OQO37_RS23275 (OQO37_23275) 4782335..4782772 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
OQO37_RS23280 (OQO37_23280) 4782769..4783650 - 882 WP_003861949.1 virulence factor BrkB family protein -
OQO37_RS23285 (OQO37_23285) 4783644..4784243 - 600 WP_003861947.1 glucose-1-phosphatase -
OQO37_RS23290 (OQO37_23290) 4784362..4785162 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T264385 WP_015569913.1 NZ_CP110857:c4779976-4779605 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT264385 WP_015569912.1 NZ_CP110857:c4780221-4779979 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References