Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3904589..3905246 Replicon chromosome
Accession NZ_CP110857
Organism Enterobacter hormaechei strain K432

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag OQO37_RS19075 Protein ID WP_017382887.1
Coordinates 3904589..3904999 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag OQO37_RS19080 Protein ID WP_003863437.1
Coordinates 3904980..3905246 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQO37_RS19055 (OQO37_19055) 3900587..3902320 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
OQO37_RS19060 (OQO37_19060) 3902326..3903039 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OQO37_RS19065 (OQO37_19065) 3903068..3903964 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
OQO37_RS19070 (OQO37_19070) 3904066..3904587 + 522 WP_015571793.1 flavodoxin FldB -
OQO37_RS19075 (OQO37_19075) 3904589..3904999 - 411 WP_017382887.1 protein YgfX Toxin
OQO37_RS19080 (OQO37_19080) 3904980..3905246 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
OQO37_RS19085 (OQO37_19085) 3905541..3906521 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
OQO37_RS19090 (OQO37_19090) 3906633..3907292 - 660 WP_003863433.1 hemolysin III family protein -
OQO37_RS19095 (OQO37_19095) 3907559..3908290 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
OQO37_RS19100 (OQO37_19100) 3908407..3909840 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T264384 WP_017382887.1 NZ_CP110857:c3904999-3904589 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT264384 WP_003863437.1 NZ_CP110857:c3905246-3904980 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References