Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2383315..2384054 Replicon chromosome
Accession NZ_CP110857
Organism Enterobacter hormaechei strain K432

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag OQO37_RS11520 Protein ID WP_017382345.1
Coordinates 2383315..2383800 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag OQO37_RS11525 Protein ID WP_003857131.1
Coordinates 2383788..2384054 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQO37_RS11500 (OQO37_11500) 2379545..2379832 + 288 WP_003033743.1 DUF2523 family protein -
OQO37_RS11505 (OQO37_11505) 2379836..2380870 + 1035 WP_234101229.1 zonular occludens toxin domain-containing protein -
OQO37_RS11510 (OQO37_11510) 2380867..2382129 + 1263 WP_234101230.1 type II secretion system protein GspD -
OQO37_RS11515 (OQO37_11515) 2382695..2383264 + 570 WP_017382346.1 hypothetical protein -
OQO37_RS11520 (OQO37_11520) 2383315..2383800 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
OQO37_RS11525 (OQO37_11525) 2383788..2384054 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
OQO37_RS11530 (OQO37_11530) 2384118..2385047 - 930 WP_023303744.1 LysR family transcriptional regulator -
OQO37_RS11535 (OQO37_11535) 2385177..2386565 + 1389 WP_032619651.1 MFS transporter -
OQO37_RS11540 (OQO37_11540) 2386587..2387582 - 996 WP_023303746.1 DUF2891 domain-containing protein -
OQO37_RS11545 (OQO37_11545) 2387592..2388578 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2347961..2384054 36093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T264377 WP_017382345.1 NZ_CP110857:c2383800-2383315 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT264377 WP_003857131.1 NZ_CP110857:c2384054-2383788 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References