264371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1241203..1242120 Replicon chromosome
Accession NZ_CP110847
Organism Bacillus velezensis strain SGTSH 0811

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag OGV27_RS06500 Protein ID WP_007407256.1
Coordinates 1241374..1242120 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag OGV27_RS06495 Protein ID WP_003154807.1
Coordinates 1241203..1241373 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV27_RS06455 (OGV27_06455) 1236436..1238058 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
OGV27_RS06460 (OGV27_06460) 1238071..1238442 + 372 WP_032874603.1 XkdW family protein -
OGV27_RS06465 (OGV27_06465) 1238447..1238644 + 198 WP_032874605.1 XkdX family protein -
OGV27_RS06470 (OGV27_06470) 1238701..1239462 + 762 WP_032874607.1 hypothetical protein -
OGV27_RS06475 (OGV27_06475) 1239514..1239777 + 264 WP_003154815.1 hemolysin XhlA family protein -
OGV27_RS06480 (OGV27_06480) 1239791..1240054 + 264 WP_003154813.1 phage holin -
OGV27_RS06485 (OGV27_06485) 1240068..1240946 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
OGV27_RS06490 (OGV27_06490) 1240981..1241106 - 126 WP_003154809.1 hypothetical protein -
OGV27_RS06495 (OGV27_06495) 1241203..1241373 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
OGV27_RS06500 (OGV27_06500) 1241374..1242120 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OGV27_RS06505 (OGV27_06505) 1242225..1243223 - 999 WP_032874611.1 inorganic phosphate transporter -
OGV27_RS06510 (OGV27_06510) 1243236..1243853 - 618 WP_032874614.1 DUF47 domain-containing protein -
OGV27_RS06515 (OGV27_06515) 1244139..1245455 - 1317 WP_032874616.1 amino acid permease -
OGV27_RS06520 (OGV27_06520) 1245777..1246727 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1197449..1299972 102523
- inside Prophage - - 1180458..1299972 119514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T264371 WP_007407256.1 NZ_CP110847:c1242120-1241374 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT264371 WP_003154807.1 NZ_CP110847:c1241373-1241203 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References