Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 367507..368297 Replicon plasmid pAt13-2099-1-2a
Accession NZ_CP110833
Organism Agrobacterium sp. 13-2099-1-2

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A9E8LKX9
Locus tag A6U84_RS24465 Protein ID WP_035200888.1
Coordinates 367800..368297 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1S7NER6
Locus tag A6U84_RS24460 Protein ID WP_019565754.1
Coordinates 367507..367803 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6U84_RS24440 (A6U84_24440) 362920..364644 + 1725 WP_003517188.1 ABC transporter ATP-binding protein -
A6U84_RS24445 (A6U84_24445) 364689..365876 + 1188 WP_065703164.1 galactarate dehydratase -
A6U84_RS24450 (A6U84_24450) 365863..366729 + 867 WP_065703249.1 aldose 1-epimerase -
A6U84_RS24455 (A6U84_24455) 366939..367268 + 330 Protein_340 DDE-type integrase/transposase/recombinase -
A6U84_RS24460 (A6U84_24460) 367507..367803 + 297 WP_019565754.1 DUF1778 domain-containing protein Antitoxin
A6U84_RS24465 (A6U84_24465) 367800..368297 + 498 WP_035200888.1 GNAT family N-acetyltransferase Toxin
A6U84_RS24470 (A6U84_24470) 368668..368925 - 258 Protein_343 DoxX family protein -
A6U84_RS24475 (A6U84_24475) 368942..369349 + 408 Protein_344 SDR family NAD(P)-dependent oxidoreductase -
A6U84_RS24480 (A6U84_24480) 369515..369766 + 252 Protein_345 CopG family transcriptional regulator -
A6U84_RS24485 (A6U84_24485) 369958..370470 + 513 WP_065703168.1 RNA polymerase sigma factor -
A6U84_RS24490 (A6U84_24490) 370593..371546 + 954 WP_065703170.1 FecR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..611263 611263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-142)

Antitoxin

Vibrio phage ICP1, Orf50

(16-90)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17726.26 Da        Isoelectric Point: 6.4803

>T264369 WP_035200888.1 NZ_CP110833:367800-368297 [Agrobacterium sp. 13-2099-1-2]
VTLSAPVPLADHHELAEFNSGVPELDDWLRRRARANQAGGASRTFVVCDESRVIAYYALASGSVKPPEVPGRFRRNMPDP
IPVAVLGRLAIDQSCQGRGIGRALVRDAGLRLLNAAEVLGIRGVLVHAISDDARAFYEAVGFLSSPSDPMMLMVGLHDLD
NALNT

Download         Length: 498 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11022.59 Da        Isoelectric Point: 7.0159

>AT264369 WP_019565754.1 NZ_CP110833:367507-367803 [Agrobacterium sp. 13-2099-1-2]
MPTSHTGKSPDASVPLNMRIKPATRNLIDRAAELLGKTRTDFMLEASERRAEEVLLDRTIVTVSPEIYAEYLARLDAPAQ
PNERLKRTMSTKAPWDEA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S7NER6

References