Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2033439..2034949 Replicon chromosome
Accession NZ_CP110832
Organism Agrobacterium sp. 13-2099-1-2

Toxin (Protein)


Gene name HipA1 Uniprot ID F0LBK0
Locus tag A6U84_RS22695 Protein ID WP_013762466.1
Coordinates 2033708..2034949 (+) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID F0LBJ9
Locus tag A6U84_RS22690 Protein ID WP_013762465.1
Coordinates 2033439..2033711 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6U84_RS22645 (A6U84_22645) 2028525..2028926 - 402 WP_013762456.1 hypothetical protein -
A6U84_RS22650 (A6U84_22650) 2028965..2029180 - 216 WP_019567388.1 hypothetical protein -
A6U84_RS22655 (A6U84_22655) 2029521..2029643 + 123 WP_003518941.1 hypothetical protein -
A6U84_RS22660 (A6U84_22660) 2029844..2030503 - 660 WP_013762458.1 porin family protein -
A6U84_RS22665 (A6U84_22665) 2030711..2031094 - 384 WP_025594780.1 ester cyclase -
A6U84_RS22670 (A6U84_22670) 2031165..2031785 - 621 WP_025594779.1 histidine phosphatase family protein -
A6U84_RS22675 (A6U84_22675) 2031763..2032332 - 570 Protein_1802 AAA family ATPase -
A6U84_RS22680 (A6U84_22680) 2032445..2032573 - 129 WP_003518932.1 hypothetical protein -
A6U84_RS22685 (A6U84_22685) 2032697..2033017 - 321 WP_065687637.1 hypothetical protein -
A6U84_RS22690 (A6U84_22690) 2033439..2033711 + 273 WP_013762465.1 helix-turn-helix domain-containing protein Antitoxin
A6U84_RS22695 (A6U84_22695) 2033708..2034949 + 1242 WP_013762466.1 type II toxin-antitoxin system HipA family toxin Toxin
A6U84_RS22700 (A6U84_22700) 2034939..2035079 + 141 WP_156390030.1 hypothetical protein -
A6U84_RS22705 (A6U84_22705) 2035530..2035718 - 189 WP_025594778.1 hypothetical protein -
A6U84_RS22710 (A6U84_22710) 2036102..2037196 + 1095 WP_065704070.1 helix-turn-helix transcriptional regulator -
A6U84_RS22715 (A6U84_22715) 2037830..2037955 + 126 WP_256372464.1 hypothetical protein -
A6U84_RS22720 (A6U84_22720) 2038568..2038840 + 273 WP_029658823.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
A6U84_RS22725 (A6U84_22725) 2038827..2038949 + 123 Protein_1812 plasmid maintenance toxin (PemK-like) -
A6U84_RS22730 (A6U84_22730) 2039121..2039330 + 210 WP_139104336.1 hypothetical protein -
A6U84_RS22735 (A6U84_22735) 2039526..2039798 + 273 WP_236735824.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 45352.22 Da        Isoelectric Point: 7.8873

>T264367 WP_013762466.1 NZ_CP110832:2033708-2034949 [Agrobacterium sp. 13-2099-1-2]
MTTIYYETLPVAHLTFEGEWRLDYDPGWEARRPAFPVSLTMPLRSGSVGAAKLLPWLANLLPETHLAEIGQRFKVSPQDI
VGLLAHIGRDTAGALSIGEPRKAGVNLRPVPDEQALERILNELPAKPFLVGERGVSMSLAGVQEKLPVFVDGNGRISVPV
DGTPSTHILKPDTKRLAGSVENEAFCLSLARACGLEAAEATIGVAGKRRYLLVKRYDRFTDPQGEIRRLHQEDLCQLTGC
FPSQKYERSSTGRGVTMKMMFDAVSDLVSPGERLKLLDAVIFNVLICNSDSHAKNYSILIGAGGSAKMAPLYDLMCAAVY
RQVDQSLPQGIFGRFHAPDLRRADWQALADDIGLSGASTLKRVGELAKLVSVACDEVAPYIVALSSDPTRILERITHSVQ
KRCRRIQEQMHDR

Download         Length: 1242 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.07 Da        Isoelectric Point: 6.2834

>AT264367 WP_013762465.1 NZ_CP110832:2033439-2033711 [Agrobacterium sp. 13-2099-1-2]
MFRSARDFGAAIKERRKALGWTQTGLAARSGTGERFIVELESGKPSCQLEKALIVARAVGIDLGDLKTVQTVQVASDDDL
GFLPMFGADQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0LBK0

Antitoxin

Source ID Structure
AlphaFold DB F0LBJ9

References