Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3763975..3764632 Replicon chromosome
Accession NZ_CP110823
Organism Enterobacter roggenkampii strain WS22-2

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag OM419_RS17580 Protein ID WP_021242050.1
Coordinates 3763975..3764385 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag OM419_RS17585 Protein ID WP_006178375.1
Coordinates 3764366..3764632 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM419_RS17560 (OM419_17555) 3759968..3761701 - 1734 WP_277737904.1 single-stranded-DNA-specific exonuclease RecJ -
OM419_RS17565 (OM419_17560) 3761707..3762420 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OM419_RS17570 (OM419_17565) 3762449..3763345 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
OM419_RS17575 (OM419_17570) 3763447..3763968 + 522 WP_277737905.1 flavodoxin FldB -
OM419_RS17580 (OM419_17575) 3763975..3764385 - 411 WP_021242050.1 protein YgfX Toxin
OM419_RS17585 (OM419_17580) 3764366..3764632 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
OM419_RS17590 (OM419_17585) 3764927..3765907 + 981 WP_008499712.1 tRNA-modifying protein YgfZ -
OM419_RS17595 (OM419_17590) 3765992..3766651 - 660 WP_032653297.1 hemolysin III family protein -
OM419_RS17600 (OM419_17595) 3766917..3767648 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
OM419_RS17605 (OM419_17600) 3767765..3769198 + 1434 WP_277737906.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T264365 WP_021242050.1 NZ_CP110823:c3764385-3763975 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT264365 WP_006178375.1 NZ_CP110823:c3764632-3764366 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References