Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1665738..1666535 Replicon chromosome
Accession NZ_CP110823
Organism Enterobacter roggenkampii strain WS22-2

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OM419_RS07795 Protein ID WP_277738336.1
Coordinates 1666014..1666535 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OM419_RS07790 Protein ID WP_008499829.1
Coordinates 1665738..1666007 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM419_RS07760 (OM419_07755) 1661361..1661804 - 444 WP_008499834.1 helix-turn-helix domain-containing protein -
OM419_RS07765 (OM419_07760) 1661957..1663198 + 1242 WP_277738335.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
OM419_RS07770 (OM419_07765) 1663234..1663461 - 228 WP_008499832.1 YccJ family protein -
OM419_RS07775 (OM419_07770) 1663482..1664078 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
OM419_RS07780 (OM419_07775) 1664470..1664640 + 171 WP_013097201.1 general stress protein -
OM419_RS07785 (OM419_07780) 1664759..1665676 + 918 WP_023292825.1 DMT family transporter -
OM419_RS07790 (OM419_07785) 1665738..1666007 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OM419_RS07795 (OM419_07790) 1666014..1666535 + 522 WP_277738336.1 N-acetyltransferase Toxin
OM419_RS07800 (OM419_07795) 1666609..1667931 - 1323 WP_277738337.1 pyrimidine utilization transport protein G -
OM419_RS07805 (OM419_07800) 1667953..1668447 - 495 WP_123922610.1 pyrimidine utilization flavin reductase protein F -
OM419_RS07810 (OM419_07805) 1668457..1669047 - 591 WP_023327079.1 malonic semialdehyde reductase -
OM419_RS07815 (OM419_07810) 1669057..1669857 - 801 WP_277738338.1 pyrimidine utilization protein D -
OM419_RS07820 (OM419_07815) 1669865..1670251 - 387 WP_008499822.1 pyrimidine utilization protein C -
OM419_RS07825 (OM419_07820) 1670263..1670952 - 690 WP_047745127.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19703.44 Da        Isoelectric Point: 7.4313

>T264359 WP_277738336.1 NZ_CP110823:1666014-1666535 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYNFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFISLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT264359 WP_008499829.1 NZ_CP110823:1665738-1666007 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References