Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1037045..1037665 Replicon chromosome
Accession NZ_CP110823
Organism Enterobacter roggenkampii strain WS22-2

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OM419_RS04805 Protein ID WP_008499287.1
Coordinates 1037045..1037263 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OM419_RS04810 Protein ID WP_008499288.1
Coordinates 1037291..1037665 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM419_RS04775 (OM419_04775) 1033058..1033318 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
OM419_RS04780 (OM419_04780) 1033321..1033461 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OM419_RS04785 (OM419_04785) 1033458..1034168 - 711 WP_277738229.1 GNAT family protein -
OM419_RS04790 (OM419_04790) 1034270..1035730 + 1461 WP_277738230.1 PLP-dependent aminotransferase family protein -
OM419_RS04795 (OM419_04795) 1035702..1036169 - 468 WP_008499285.1 YlaC family protein -
OM419_RS04800 (OM419_04800) 1036287..1036838 - 552 WP_008499286.1 maltose O-acetyltransferase -
OM419_RS04805 (OM419_04805) 1037045..1037263 - 219 WP_008499287.1 HHA domain-containing protein Toxin
OM419_RS04810 (OM419_04810) 1037291..1037665 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OM419_RS04815 (OM419_04815) 1038175..1041321 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
OM419_RS04820 (OM419_04820) 1041344..1042537 - 1194 WP_232927929.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T264358 WP_008499287.1 NZ_CP110823:c1037263-1037045 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT264358 WP_008499288.1 NZ_CP110823:c1037665-1037291 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References