Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 44118..44779 Replicon chromosome
Accession NZ_CP110823
Organism Enterobacter roggenkampii strain WS22-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OM419_RS00220 Protein ID WP_023293716.1
Coordinates 44381..44779 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A156KC23
Locus tag OM419_RS00215 Protein ID WP_032675702.1
Coordinates 44118..44384 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM419_RS00190 (OM419_00190) 40171..41499 - 1329 WP_023326395.1 PTS sugar transporter subunit IIC -
OM419_RS00195 (OM419_00195) 41511..41825 - 315 WP_087450466.1 PTS sugar transporter subunit IIB -
OM419_RS00200 (OM419_00200) 42119..43069 + 951 WP_023293714.1 LacI family DNA-binding transcriptional regulator -
OM419_RS00205 (OM419_00205) 43131..43427 - 297 WP_021242704.1 YicS family protein -
OM419_RS00210 (OM419_00210) 43569..43988 + 420 WP_008500129.1 GNAT family N-acetyltransferase -
OM419_RS00215 (OM419_00215) 44118..44384 + 267 WP_032675702.1 virulence protein Antitoxin
OM419_RS00220 (OM419_00220) 44381..44779 + 399 WP_023293716.1 type II toxin-antitoxin system VapC family toxin Toxin
OM419_RS00225 (OM419_00225) 44919..45719 + 801 WP_277738043.1 lipoprotein NlpA -
OM419_RS00230 (OM419_00230) 45842..46621 + 780 WP_277738044.1 MBL fold metallo-hydrolase -
OM419_RS00235 (OM419_00235) 46648..47601 + 954 WP_055321086.1 helix-turn-helix domain-containing protein -
OM419_RS00240 (OM419_00240) 47784..49481 + 1698 WP_277738540.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14799.00 Da        Isoelectric Point: 6.4779

>T264356 WP_023293716.1 NZ_CP110823:44381-44779 [Enterobacter roggenkampii]
MRHMLDTNIVSHLFKRHPEVVSRMTCLAPGDVCISSITEAELLYGADKKKSSRLKETIREFLNTITICDWDSDAAATYGE
LRATLEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFRMVQELAVEDWTTTL

Download         Length: 399 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10009.34 Da        Isoelectric Point: 4.6310

>AT264356 WP_032675702.1 NZ_CP110823:44118-44384 [Enterobacter roggenkampii]
MERTAKLFRKGQNQAVMLPAEFAFDTESVYIRRDEEGNVVLAAKPVLIKSWDNFLRMLAETDVPDTFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A156KC23

References