Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 48339..48861 Replicon plasmid pHB42-F5
Accession NZ_CP110817
Organism Escherichia coli strain THB42-F5

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag N0566_RS22625 Protein ID WP_000220561.1
Coordinates 48580..48861 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N0566_RS22620 Protein ID WP_000121743.1
Coordinates 48339..48590 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0566_RS22600 (44462) 44462..44815 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
N0566_RS22605 (44952) 44952..45398 - 447 WP_001074384.1 hypothetical protein -
N0566_RS22610 (45402) 45402..46244 - 843 WP_000435064.1 replication initiation protein -
N0566_RS22615 (46265) 46265..47104 - 840 WP_024129959.1 replication initiation protein -
N0566_RS22620 (48339) 48339..48590 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N0566_RS22625 (48580) 48580..48861 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0566_RS22630 (49100) 49100..49192 - 93 Protein_51 IS6 family transposase -
N0566_RS22635 (49358) 49358..50557 - 1200 WP_000948429.1 IS91 family transposase -
N0566_RS22640 (50567) 50567..50755 - 189 WP_000957857.1 hypothetical protein -
N0566_RS22645 (50875) 50875..52305 + 1431 Protein_54 IS4-like element IS50R family transposase -
N0566_RS22650 (52334) 52334..53128 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
N0566_RS22655 (53149) 53149..53385 + 237 Protein_56 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / aph(3')-IIa / dfrA12 / aadA2 / qacE / mph(A) / blaTEM-1B / rmtB / blaCTX-M-55 - 1..161920 161920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T264351 WP_000220561.1 NZ_CP110817:48580-48861 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT264351 WP_000121743.1 NZ_CP110817:48339-48590 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References