Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 20880..21439 Replicon plasmid pHB42-F5
Accession NZ_CP110817
Organism Escherichia coli strain THB42-F5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N0566_RS22460 Protein ID WP_226156935.1
Coordinates 21164..21439 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N0566_RS22455 Protein ID WP_075858633.1
Coordinates 20880..21164 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0566_RS22445 (18946) 18946..19694 + 749 Protein_14 ISKra4 family transposase -
N0566_RS22450 (20055) 20055..20573 - 519 WP_259904984.1 DUF4238 domain-containing protein -
N0566_RS22455 (20880) 20880..21164 + 285 WP_075858633.1 ribbon-helix-helix protein, CopG family Antitoxin
N0566_RS22460 (21164) 21164..21439 + 276 WP_226156935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0566_RS22465 (21546) 21546..21749 + 204 Protein_18 hypothetical protein -
N0566_RS22470 (22046) 22046..22345 + 300 WP_226156930.1 hypothetical protein -
N0566_RS22480 (23174) 23174..24688 - 1515 Protein_21 Tn3-like element TnAs1 family transposase -
N0566_RS22485 (24754) 24754..25458 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
N0566_RS22490 (25511) 25511..26266 + 756 Protein_23 IS110-like element IS5075 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / aph(3')-IIa / dfrA12 / aadA2 / qacE / mph(A) / blaTEM-1B / rmtB / blaCTX-M-55 - 1..161920 161920
- inside IScluster/Tn sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR - 19141..38728 19587


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10726.41 Da        Isoelectric Point: 10.0872

>T264350 WP_226156935.1 NZ_CP110817:21164-21439 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLSSKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIH
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10493.96 Da        Isoelectric Point: 6.4613

>AT264350 WP_075858633.1 NZ_CP110817:20880-21164 [Escherichia coli]
MQMKNNSAQATKVITAHVPLLMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEAMDDVTSGQVINHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References