Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3950807..3951621 Replicon chromosome
Accession NZ_CP110816
Organism Escherichia coli strain THB42-F5

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag N0566_RS19280 Protein ID WP_001054376.1
Coordinates 3950807..3951064 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag N0566_RS19285 Protein ID WP_001309181.1
Coordinates 3951076..3951621 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0566_RS19255 (3946095) 3946095..3947201 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
N0566_RS19260 (3947266) 3947266..3948246 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
N0566_RS19265 (3948356) 3948356..3948561 + 206 Protein_3761 HNH endonuclease -
N0566_RS19270 (3948829) 3948829..3950069 - 1241 Protein_3762 helicase YjhR -
N0566_RS19275 (3950185) 3950185..3950316 + 132 WP_001309182.1 hypothetical protein -
N0566_RS19280 (3950807) 3950807..3951064 + 258 WP_001054376.1 YjhX family toxin Toxin
N0566_RS19285 (3951076) 3951076..3951621 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
N0566_RS19290 (3951677) 3951677..3952423 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
N0566_RS19295 (3952592) 3952592..3952810 + 219 Protein_3767 hypothetical protein -
N0566_RS19300 (3952848) 3952848..3952964 + 117 Protein_3768 VOC family protein -
N0566_RS19305 (3953209) 3953209..3954330 + 1122 WP_000010829.1 M42 family metallopeptidase -
N0566_RS19310 (3954327) 3954327..3954605 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
N0566_RS19315 (3954617) 3954617..3955930 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 3939817..3959845 20028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T264347 WP_001054376.1 NZ_CP110816:3950807-3951064 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT264347 WP_001309181.1 NZ_CP110816:3951076-3951621 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References