Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3037412..3038075 Replicon chromosome
Accession NC_017309
Organism Edwardsiella tarda FL6-60

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag ETAF_RS13415 Protein ID WP_034167931.1
Coordinates 3037412..3037828 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag ETAF_RS13420 Protein ID WP_012849755.1
Coordinates 3037809..3038075 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETAF_RS13395 3033343..3035076 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
ETAF_RS13400 3035081..3035797 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ETAF_RS13405 3035825..3036724 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
ETAF_RS13410 3036875..3037387 + 513 WP_012849753.1 flavodoxin FldB -
ETAF_RS13415 3037412..3037828 - 417 WP_034167931.1 protein YgfX Toxin
ETAF_RS13420 3037809..3038075 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
ETAF_RS13425 3038429..3039427 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
ETAF_RS13430 3039470..3040294 - 825 WP_012849757.1 shikimate 5-dehydrogenase -
ETAF_RS13435 3040453..3041325 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
ETAF_RS13440 3041934..3042584 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T26432 WP_034167931.1 NC_017309:c3037828-3037412 [Edwardsiella tarda FL6-60]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T26432 NC_017309:c3037828-3037412 [Edwardsiella tarda FL6-60]
GTGGTCCTTTGGCGCTGTAATGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTACT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGCCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGACGCCCTTGGGTTAGCGATCTGGGGGCGCTGCTGATCCTGCAGAGTACCCATGGTGCGCCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATGCGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT26432 WP_012849755.1 NC_017309:c3038075-3037809 [Edwardsiella tarda FL6-60]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT26432 NC_017309:c3038075-3037809 [Edwardsiella tarda FL6-60]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCCATCATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGTGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGATGACGCCGATCTGGCCCGCATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References