Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ypjF-yeeU/CbtA-CbeA |
| Location | 2832755..2833487 | Replicon | chromosome |
| Accession | NC_017309 | ||
| Organism | Edwardsiella tarda FL6-60 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A411H496 |
| Locus tag | ETAF_RS17000 | Protein ID | WP_015683453.1 |
| Coordinates | 2833158..2833487 (+) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A411H489 |
| Locus tag | ETAF_RS12500 | Protein ID | WP_015683452.1 |
| Coordinates | 2832755..2833120 (+) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETAF_RS12460 | 2827997..2828710 | + | 714 | WP_041692656.1 | WYL domain-containing protein | - |
| ETAF_RS12465 | 2828707..2829327 | + | 621 | WP_041692657.1 | hypothetical protein | - |
| ETAF_RS12470 | 2829362..2829814 | + | 453 | WP_015683446.1 | hypothetical protein | - |
| ETAF_RS12475 | 2829811..2830260 | + | 450 | WP_015683447.1 | hypothetical protein | - |
| ETAF_RS12480 | 2830332..2830562 | + | 231 | WP_015683448.1 | DUF905 domain-containing protein | - |
| ETAF_RS12485 | 2830661..2831482 | + | 822 | WP_041692658.1 | DUF945 domain-containing protein | - |
| ETAF_RS12490 | 2831513..2831956 | + | 444 | Protein_2469 | antirestriction protein | - |
| ETAF_RS12495 | 2831969..2832511 | + | 543 | WP_041692659.1 | DNA repair protein RadC | - |
| ETAF_RS16995 | 2832508..2832729 | + | 222 | WP_015683451.1 | DUF987 domain-containing protein | - |
| ETAF_RS12500 | 2832755..2833120 | + | 366 | WP_015683452.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ETAF_RS17000 | 2833158..2833487 | + | 330 | WP_015683453.1 | TA system toxin CbtA family protein | Toxin |
| ETAF_RS12505 | 2833867..2834163 | + | 297 | WP_012849576.1 | hypothetical protein | - |
| ETAF_RS12510 | 2834280..2834666 | - | 387 | WP_012849577.1 | RidA family protein | - |
| ETAF_RS12515 | 2834703..2835029 | - | 327 | WP_012849578.1 | AzlD domain-containing protein | - |
| ETAF_RS12520 | 2835022..2835759 | - | 738 | WP_172454870.1 | AzlC family ABC transporter permease | - |
| ETAF_RS12525 | 2835823..2837106 | - | 1284 | WP_012849580.1 | serine dehydratase subunit alpha family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2808546..2833487 | 24941 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12617.29 Da Isoelectric Point: 9.5061
>T26431 WP_015683453.1 NC_017309:2833158-2833487 [Edwardsiella tarda FL6-60]
MQTLSSHPTRSTQPYLSPVETWQRLLTHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYELIRIDRKGF
SWQQQTPYISVVDILRARRNTGLLKTNVK
MQTLSSHPTRSTQPYLSPVETWQRLLTHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYELIRIDRKGF
SWQQQTPYISVVDILRARRNTGLLKTNVK
Download Length: 330 bp
>T26431 NC_017309:2833158-2833487 [Edwardsiella tarda FL6-60]
ATGCAAACCTTATCATCACACCCGACACGGTCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTATTCTCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGAAACCACCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGAGCTTATCCGTATCGATCGGAAGGGATTT
TCGTGGCAACAACAGACTCCGTATATTTCCGTAGTGGATATTCTACGAGCAAGACGCAATACCGGCTTGCTAAAAACTAA
TGTGAAATAA
ATGCAAACCTTATCATCACACCCGACACGGTCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTATTCTCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGAAACCACCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGAGCTTATCCGTATCGATCGGAAGGGATTT
TCGTGGCAACAACAGACTCCGTATATTTCCGTAGTGGATATTCTACGAGCAAGACGCAATACCGGCTTGCTAAAAACTAA
TGTGAAATAA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13477.21 Da Isoelectric Point: 5.8743
>AT26431 WP_015683452.1 NC_017309:2832755-2833120 [Edwardsiella tarda FL6-60]
MNNHSESGTKPENLTCQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLTSGE
LSPLHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPDQPEPH
MNNHSESGTKPENLTCQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLTSGE
LSPLHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPDQPEPH
Download Length: 366 bp
>AT26431 NC_017309:2832755-2833120 [Edwardsiella tarda FL6-60]
ATGAACAATCACTCTGAATCCGGTACCAAACCGGAGAATCTTACCTGCCAGCAGTGGGGACTAAAGCGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGGCAACCGGGTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACAACGATGCATTGCGCCTCGACCAGGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTCACCAGCGGAGAA
CTCTCTCCCTTGCATCAGCACTGCGTCACGCTATATCACAATGGACTGACTTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATCGCTATTTATCCCGACCAGCCTGAACCCCATTAA
ATGAACAATCACTCTGAATCCGGTACCAAACCGGAGAATCTTACCTGCCAGCAGTGGGGACTAAAGCGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGGCAACCGGGTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACAACGATGCATTGCGCCTCGACCAGGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTCACCAGCGGAGAA
CTCTCTCCCTTGCATCAGCACTGCGTCACGCTATATCACAATGGACTGACTTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATCGCTATTTATCCCGACCAGCCTGAACCCCATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A411H496 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A411H489 |