Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1091185..1091777 Replicon chromosome
Accession NC_017309
Organism Edwardsiella tarda FL6-60

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag ETAF_RS04745 Protein ID WP_012847872.1
Coordinates 1091185..1091388 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D0ZEC3
Locus tag ETAF_RS04750 Protein ID WP_012847873.1
Coordinates 1091409..1091777 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETAF_RS04720 1086862..1087323 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
ETAF_RS04725 1087628..1087966 + 339 WP_012847867.1 P-II family nitrogen regulator -
ETAF_RS04730 1087988..1089268 + 1281 WP_041692495.1 ammonium transporter AmtB -
ETAF_RS04735 1089303..1090169 - 867 WP_012847869.1 acyl-CoA thioesterase II -
ETAF_RS04740 1090278..1090634 - 357 WP_012847870.1 MGMT family protein -
ETAF_RS04745 1091185..1091388 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
ETAF_RS04750 1091409..1091777 - 369 WP_012847873.1 Hha toxicity modulator TomB Antitoxin
ETAF_RS04755 1092145..1095297 - 3153 WP_012847874.1 multidrug efflux RND transporter permease subunit -
ETAF_RS04760 1095341..1096525 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T26430 WP_012847872.1 NC_017309:c1091388-1091185 [Edwardsiella tarda FL6-60]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T26430 NC_017309:c1091388-1091185 [Edwardsiella tarda FL6-60]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14129.83 Da        Isoelectric Point: 6.1484

>AT26430 WP_012847873.1 NC_017309:c1091777-1091409 [Edwardsiella tarda FL6-60]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNATLHV

Download         Length: 369 bp

>AT26430 NC_017309:c1091777-1091409 [Edwardsiella tarda FL6-60]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTACCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB D0ZEC3

References