Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4298603..4299226 Replicon chromosome
Accession NZ_CP110809
Organism Pseudomonas syringae strain MUP32

Toxin (Protein)


Gene name hicA Uniprot ID A0A3M3C685
Locus tag OQB64_RS19015 Protein ID WP_003314536.1
Coordinates 4299044..4299226 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3M3C5W4
Locus tag OQB64_RS19010 Protein ID WP_010421644.1
Coordinates 4298603..4299007 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQB64_RS18995 (OQB64_18995) 4294369..4295037 + 669 WP_024648672.1 ABC transporter ATP-binding protein -
OQB64_RS19000 (OQB64_19000) 4295037..4297517 + 2481 WP_024648671.1 ABC transporter permease -
OQB64_RS19005 (OQB64_19005) 4297507..4298586 + 1080 WP_024648670.1 lipocalin-like domain-containing protein -
OQB64_RS19010 (OQB64_19010) 4298603..4299007 - 405 WP_010421644.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OQB64_RS19015 (OQB64_19015) 4299044..4299226 - 183 WP_003314536.1 type II toxin-antitoxin system HicA family toxin Toxin
OQB64_RS19020 (OQB64_19020) 4299510..4301282 + 1773 WP_004416697.1 N-acetylglutaminylglutamine amidotransferase -
OQB64_RS19025 (OQB64_19025) 4301286..4303034 + 1749 WP_003418255.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6763.96 Da        Isoelectric Point: 10.6643

>T264283 WP_003314536.1 NZ_CP110809:c4299226-4299044 [Pseudomonas syringae]
VQSRQLIKELEADGWVLDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14568.66 Da        Isoelectric Point: 5.5960

>AT264283 WP_010421644.1 NZ_CP110809:c4299007-4298603 [Pseudomonas syringae]
MKYPMCIEWGNETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAASGRTIPKAGNVAEHARNPDFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3C685

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3C5W4

References