Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4266375..4266998 Replicon chromosome
Accession NZ_CP110807
Organism Pseudomonas syringae strain MUP17

Toxin (Protein)


Gene name hicA Uniprot ID A0A3M3C685
Locus tag OQB66_RS18035 Protein ID WP_003314536.1
Coordinates 4266816..4266998 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3M3C5W4
Locus tag OQB66_RS18030 Protein ID WP_010421644.1
Coordinates 4266375..4266779 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQB66_RS18015 (OQB66_18015) 4262141..4262809 + 669 WP_004416701.1 ABC transporter ATP-binding protein -
OQB66_RS18020 (OQB66_18020) 4262809..4265289 + 2481 WP_046719103.1 ABC transporter permease -
OQB66_RS18025 (OQB66_18025) 4265279..4266358 + 1080 WP_266064573.1 lipocalin-like domain-containing protein -
OQB66_RS18030 (OQB66_18030) 4266375..4266779 - 405 WP_010421644.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OQB66_RS18035 (OQB66_18035) 4266816..4266998 - 183 WP_003314536.1 type II toxin-antitoxin system HicA family toxin Toxin
OQB66_RS18040 (OQB66_18040) 4267283..4269055 + 1773 WP_266064575.1 N-acetylglutaminylglutamine amidotransferase -
OQB66_RS18045 (OQB66_18045) 4269059..4270807 + 1749 WP_003418255.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6763.96 Da        Isoelectric Point: 10.6643

>T264276 WP_003314536.1 NZ_CP110807:c4266998-4266816 [Pseudomonas syringae]
VQSRQLIKELEADGWVLDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14568.66 Da        Isoelectric Point: 5.5960

>AT264276 WP_010421644.1 NZ_CP110807:c4266779-4266375 [Pseudomonas syringae]
MKYPMCIEWGNETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAASGRTIPKAGNVAEHARNPDFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3C685

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3C5W4

References