Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 856..1457 Replicon plasmid unnamed2
Accession NZ_CP110801
Organism Lactiplantibacillus plantarum strain BRD_L15

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag OP868_RS15340 Protein ID WP_001748110.1
Coordinates 856..1200 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q684P2
Locus tag OP868_RS15345 Protein ID WP_003643337.1
Coordinates 1194..1457 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP868_RS15335 (OP868_15335) 1..5669 - 5669 WP_003587210.1 DNA starvation/stationary phase protection protein -
OP868_RS15340 (OP868_15340) 856..1200 - 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OP868_RS15345 (OP868_15345) 1194..1457 - 264 WP_003643337.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OP868_RS15350 (OP868_15350) 1543..2130 + 588 WP_103758603.1 site-specific integrase -
OP868_RS15355 (OP868_15355) 4213..4383 - 171 WP_157949630.1 hypothetical protein -
OP868_RS15360 (OP868_15360) 4661..5164 - 504 WP_103758604.1 DUF536 domain-containing protein -
OP868_RS15365 (OP868_15365) 5390..5479 + 90 Protein_6 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..5669 5669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-104)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13041.89 Da        Isoelectric Point: 6.4782

>T264267 WP_001748110.1 NZ_CP110801:c1200-856 [Lactiplantibacillus plantarum]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.51 Da        Isoelectric Point: 6.4708

>AT264267 WP_003643337.1 NZ_CP110801:c1457-1194 [Lactiplantibacillus plantarum]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWKDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L4ZZT2

References