Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3126276..3126894 Replicon chromosome
Accession NZ_CP110791
Organism Yersinia sp. SCPM-O-B-9106 (C-191)

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag OP863_RS14280 Protein ID WP_002208622.1
Coordinates 3126691..3126894 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag OP863_RS14275 Protein ID WP_265525443.1
Coordinates 3126276..3126644 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP863_RS14245 (OP863_14245) 3121950..3122210 + 261 WP_038631547.1 type B 50S ribosomal protein L31 -
OP863_RS14250 (OP863_14250) 3122226..3122369 + 144 WP_050113290.1 type B 50S ribosomal protein L36 -
OP863_RS14255 (OP863_14255) 3122491..3123369 - 879 WP_145589724.1 metal ABC transporter substrate-binding protein -
OP863_RS14260 (OP863_14260) 3123415..3124272 - 858 WP_038631544.1 metal ABC transporter permease -
OP863_RS14265 (OP863_14265) 3124269..3124997 - 729 WP_038631543.1 ABC transporter ATP-binding protein -
OP863_RS14270 (OP863_14270) 3125764..3126117 + 354 WP_265525442.1 hypothetical protein -
OP863_RS14275 (OP863_14275) 3126276..3126644 + 369 WP_265525443.1 Hha toxicity modulator TomB Antitoxin
OP863_RS14280 (OP863_14280) 3126691..3126894 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
OP863_RS14290 (OP863_14290) 3127838..3128149 + 312 WP_186368264.1 MGMT family protein -
OP863_RS14295 (OP863_14295) 3128193..3128717 - 525 WP_145589727.1 YbaY family lipoprotein -
OP863_RS14300 (OP863_14300) 3128975..3129835 + 861 WP_038631531.1 acyl-CoA thioesterase II -
OP863_RS14305 (OP863_14305) 3129917..3131206 - 1290 WP_038639390.1 ammonium transporter AmtB -
OP863_RS14310 (OP863_14310) 3131246..3131584 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T264263 WP_002208622.1 NZ_CP110791:3126691-3126894 [Yersinia sp. SCPM-O-B-9106 (C-191)]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14219.03 Da        Isoelectric Point: 4.5140

>AT264263 WP_265525443.1 NZ_CP110791:3126276-3126644 [Yersinia sp. SCPM-O-B-9106 (C-191)]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGVDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure

References