Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4225474..4227024 Replicon chromosome
Accession NZ_CP110790
Organism Yersinia massiliensis strain SCPM-O-B-8026 (C-146)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OP862_RS18965 Protein ID WP_167311328.1
Coordinates 4225474..4226769 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OP862_RS18970 Protein ID WP_050080817.1
Coordinates 4226773..4227024 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP862_RS18940 (OP862_18940) 4221255..4222256 + 1002 WP_019211213.1 autoinducer 2 ABC transporter permease LsrD -
OP862_RS18945 (OP862_18945) 4222337..4223356 + 1020 WP_019211214.1 autoinducer 2 ABC transporter substrate-binding protein LsrB -
OP862_RS18950 (OP862_18950) 4223412..4224287 + 876 WP_019211215.1 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase -
OP862_RS18955 (OP862_18955) 4224308..4224598 + 291 WP_019211216.1 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase -
OP862_RS18960 (OP862_18960) 4224839..4225321 + 483 WP_050080815.1 DUF2501 domain-containing protein -
OP862_RS18965 (OP862_18965) 4225474..4226769 - 1296 WP_167311328.1 type II toxin-antitoxin system HipA family toxin Toxin
OP862_RS18970 (OP862_18970) 4226773..4227024 - 252 WP_050080817.1 helix-turn-helix domain-containing protein Antitoxin
OP862_RS18975 (OP862_18975) 4227141..4227977 + 837 WP_050286206.1 aminoglycoside phosphotransferase family protein -
OP862_RS18980 (OP862_18980) 4228062..4229798 + 1737 WP_050286207.1 SulP family inorganic anion transporter -
OP862_RS18985 (OP862_18985) 4230219..4230824 + 606 WP_050878821.1 LuxR C-terminal-related transcriptional regulator -
OP862_RS18990 (OP862_18990) 4231023..4231619 - 597 WP_050286210.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-398)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 48546.94 Da        Isoelectric Point: 6.7731

>T264252 WP_167311328.1 NZ_CP110790:c4226769-4225474 [Yersinia massiliensis]
MEKLTLALNGIVVGTLEKAAGGEISFFYHDSWLERSGARAISLSLPLQTVKFRGEVVYNFFDNLLPDSESIRSRIQARFQ
TPTKQPFDLLSQIGSDCVGAIQLYPEGRQINSVTEIHATPLNDNEIEKLLLGYKEAPLGMEADIDDFRISLAGAQEKTAL
LWYQNQWHRPEGSTPTSHILKLPIGYIAANGIDLSESVENEWLCLKIAEEFGLPVAYSEIKYFGKQKALVVERFDRRWSP
NNSWLMRLPQEDFCQVLGVAPALKYESDGGPGIADAMKLLLGSQQAIQDRDIFFKSQILFWMLAAIDGHAKNFSVFIELD
SAFRMTPIYDVMSAFPLMHPRGIRAKKAKMAMALLGRNRHFHWSTILPRHFISTAKQVNYPEDNVVQLMAEMKEKTEQVI
AAVKAVLPQGFPEKISEPIFSGLRRQSAKLP

Download         Length: 1296 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9584.94 Da        Isoelectric Point: 10.4866

>AT264252 WP_050080817.1 NZ_CP110790:c4227024-4226773 [Yersinia massiliensis]
MKITSAAMLANTLRNERKKSKLTQRKTAETVGLKQSTVSEFENHPDGTKLDTLFKLLAALDLELQVRPRNRNIKDNTTWD
QEW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References