Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1035826..1036498 Replicon chromosome
Accession NZ_CP110790
Organism Yersinia massiliensis strain SCPM-O-B-8026 (C-146)

Toxin (Protein)


Gene name cptA Uniprot ID A0A0T9UGW4
Locus tag OP862_RS04510 Protein ID WP_050082213.1
Coordinates 1036073..1036498 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0T9UGT3
Locus tag OP862_RS04505 Protein ID WP_019211617.1
Coordinates 1035826..1036092 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP862_RS04490 (OP862_04490) 1032797..1033546 + 750 WP_050286433.1 SDR family oxidoreductase -
OP862_RS04495 (OP862_04495) 1033791..1034483 + 693 WP_050082335.1 hemolysin III family protein -
OP862_RS04500 (OP862_04500) 1034569..1035558 - 990 WP_050286434.1 tRNA-modifying protein YgfZ -
OP862_RS04505 (OP862_04505) 1035826..1036092 + 267 WP_019211617.1 FAD assembly factor SdhE Antitoxin
OP862_RS04510 (OP862_04510) 1036073..1036498 + 426 WP_050082213.1 protein YgfX Toxin
OP862_RS04515 (OP862_04515) 1036498..1037196 + 699 WP_050286436.1 two-component system response regulator CreB -
OP862_RS04520 (OP862_04520) 1037235..1038662 + 1428 WP_050286437.1 two-component system sensor histidine kinase CreC -
OP862_RS04525 (OP862_04525) 1038754..1040178 + 1425 WP_050286439.1 cell envelope integrity protein CreD -
OP862_RS04530 (OP862_04530) 1040269..1040787 - 519 WP_050286440.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16527.43 Da        Isoelectric Point: 9.4189

>T264243 WP_050082213.1 NZ_CP110790:1036073-1036498 [Yersinia massiliensis]
VAQWRCDLRISWHTQLFSLLTHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNVVLWKRL
EWIVVKQPWMTRYGVLLRLRQANSRSTCKRLWLAADSMSEDEWRQLCLLLRHSFDADEGHT

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10532.06 Da        Isoelectric Point: 4.6786

>AT264243 WP_019211617.1 NZ_CP110790:1035826-1036092 [Yersinia massiliensis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDGLSDSEKQIFIRLLECDDPDLFNWLMNHGEPQDDELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UGW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UGT3

References