Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 133922..134532 Replicon chromosome
Accession NZ_CP110790
Organism Yersinia massiliensis strain SCPM-O-B-8026 (C-146)

Toxin (Protein)


Gene name doc Uniprot ID A0A0T9RAE9
Locus tag OP862_RS00560 Protein ID WP_049610048.1
Coordinates 133922..134314 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0T9UY83
Locus tag OP862_RS00565 Protein ID WP_049610050.1
Coordinates 134311..134532 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP862_RS00535 (OP862_00535) 129145..129330 + 186 WP_049610039.1 hypothetical protein -
OP862_RS00540 (OP862_00540) 129536..130684 + 1149 WP_050083387.1 pectate lyase -
OP862_RS00545 (OP862_00545) 130763..130942 - 180 Protein_107 FKBP-type peptidyl-prolyl cis-trans isomerase -
OP862_RS00550 (OP862_00550) 130973..132583 - 1611 WP_050287363.1 FAD-NAD(P)-binding protein -
OP862_RS00555 (OP862_00555) 133224..133760 - 537 WP_050287364.1 cysteine hydrolase family protein -
OP862_RS00560 (OP862_00560) 133922..134314 - 393 WP_049610048.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OP862_RS00565 (OP862_00565) 134311..134532 - 222 WP_049610050.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OP862_RS00570 (OP862_00570) 134782..135645 - 864 WP_050287365.1 YicC/YloC family endoribonuclease -
OP862_RS00575 (OP862_00575) 135775..136491 + 717 WP_004705100.1 ribonuclease PH -
OP862_RS00580 (OP862_00580) 136603..137250 + 648 WP_049610089.1 orotate phosphoribosyltransferase -
OP862_RS00585 (OP862_00585) 137700..138995 + 1296 WP_050083382.1 dicarboxylate/amino acid:cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14797.78 Da        Isoelectric Point: 6.9895

>T264242 WP_049610048.1 NZ_CP110790:c134314-133922 [Yersinia massiliensis]
MMWISAQEVIAFHDRILQRLPGVTGIPDPGRAEALIYRVQNRTHYEGVTDVFELGATYWVAIARGHIFNDGNKRTAFFVT
MAFLYRNGIRIRDTDNSLENLTVAAATGEKTVDQLAQHLRDLVEHTNQIR

Download         Length: 393 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.99 Da        Isoelectric Point: 5.5675

>AT264242 WP_049610050.1 NZ_CP110790:c134532-134311 [Yersinia massiliensis]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFETYQNAKLDAEFDVIMQRHGHTVEALTNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9RAE9

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UY83

References