Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 48074..48717 Replicon chromosome
Accession NZ_CP110790
Organism Yersinia massiliensis strain SCPM-O-B-8026 (C-146)

Toxin (Protein)


Gene name vagD Uniprot ID A0A0T9UYT7
Locus tag OP862_RS00190 Protein ID WP_072084841.1
Coordinates 48074..48493 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0T9UYU4
Locus tag OP862_RS00195 Protein ID WP_049611185.1
Coordinates 48490..48717 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP862_RS00170 (OP862_00170) 43167..44021 + 855 WP_167311513.1 formate dehydrogenase accessory sulfurtransferase FdhD -
OP862_RS00175 (OP862_00175) 44148..44771 + 624 WP_167311514.1 superoxide dismutase [Mn] -
OP862_RS00180 (OP862_00180) 45093..47054 + 1962 WP_050287201.1 methyl-accepting chemotaxis protein -
OP862_RS00185 (OP862_00185) 47224..47898 + 675 WP_050083410.1 6-hydroxyaminopurine reductase -
OP862_RS00190 (OP862_00190) 48074..48493 - 420 WP_072084841.1 type II toxin-antitoxin system VapC family toxin Toxin
OP862_RS00195 (OP862_00195) 48490..48717 - 228 WP_049611185.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OP862_RS00200 (OP862_00200) 48891..49247 - 357 WP_050083411.1 YibL family ribosome-associated protein -
OP862_RS00205 (OP862_00205) 49412..50893 - 1482 WP_050083412.1 PLP-dependent aminotransferase family protein -
OP862_RS00210 (OP862_00210) 51115..51723 + 609 WP_050083413.1 LysE family translocator -
OP862_RS00215 (OP862_00215) 51725..52279 - 555 WP_019212698.1 MltR family transcriptional regulator -
OP862_RS00220 (OP862_00220) 52358..53521 - 1164 WP_050287203.1 mannitol-1-phosphate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15480.16 Da        Isoelectric Point: 9.5045

>T264240 WP_072084841.1 NZ_CP110790:c48493-48074 [Yersinia massiliensis]
MIKKIYMLDTNICSFIMRERPAEIIIKLQQCIERQNKIVVSAITYSEMRFGAIGKKASPKHTYLVEEFVKRLDAVLPWDV
AAIDATTQIKIALAKAGTPIGGNDAAIAGHAISTGAILVTNNVREFERVKKLHIEDWAN

Download         Length: 420 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8736.89 Da        Isoelectric Point: 4.2687

>AT264240 WP_049611185.1 NZ_CP110790:c48717-48490 [Yersinia massiliensis]
MRTVSIFKNGQNRAIRLPKDMDFEGVTELEIIKDGDNIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRVNL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UYT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UYU4

References