Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3574557..3575176 Replicon chromosome
Accession NZ_CP110789
Organism Yersinia intermedia strain SCPM-O-B-10209 (333)

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag OP861_RS16485 Protein ID WP_002208622.1
Coordinates 3574973..3575176 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag OP861_RS16480 Protein ID WP_265534982.1
Coordinates 3574557..3574925 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP861_RS16450 (OP861_16450) 3570189..3570461 + 273 WP_265534977.1 type B 50S ribosomal protein L31 -
OP861_RS16455 (OP861_16455) 3570464..3570607 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
OP861_RS16460 (OP861_16460) 3570774..3571652 - 879 WP_005182278.1 metal ABC transporter substrate-binding protein -
OP861_RS16465 (OP861_16465) 3571681..3572538 - 858 WP_050086000.1 metal ABC transporter permease -
OP861_RS16470 (OP861_16470) 3572535..3573272 - 738 WP_050086076.1 ABC transporter ATP-binding protein -
OP861_RS16475 (OP861_16475) 3574045..3574398 + 354 WP_050086001.1 hypothetical protein -
OP861_RS16480 (OP861_16480) 3574557..3574925 + 369 WP_265534982.1 Hha toxicity modulator TomB Antitoxin
OP861_RS16485 (OP861_16485) 3574973..3575176 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
OP861_RS16495 (OP861_16495) 3576106..3576411 + 306 WP_186004081.1 MGMT family protein -
OP861_RS16500 (OP861_16500) 3576502..3577056 - 555 WP_226717834.1 YbaY family lipoprotein -
OP861_RS16505 (OP861_16505) 3577315..3578175 + 861 WP_226717835.1 acyl-CoA thioesterase II -
OP861_RS16510 (OP861_16510) 3578266..3579555 - 1290 WP_050135642.1 ammonium transporter AmtB -
OP861_RS16515 (OP861_16515) 3579595..3579933 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T264239 WP_002208622.1 NZ_CP110789:3574973-3575176 [Yersinia intermedia]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14188.91 Da        Isoelectric Point: 4.4314

>AT264239 WP_265534982.1 NZ_CP110789:3574557-3574925 [Yersinia intermedia]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLLRLFSGEYTCTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure

References