Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2234275..2235265 Replicon chromosome
Accession NZ_CP110789
Organism Yersinia intermedia strain SCPM-O-B-10209 (333)

Toxin (Protein)


Gene name - Uniprot ID A0A209A434
Locus tag OP861_RS10130 Protein ID WP_050085270.1
Coordinates 2234275..2234733 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T9M4Z0
Locus tag OP861_RS10135 Protein ID WP_005184401.1
Coordinates 2234819..2235265 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP861_RS10100 (OP861_10100) 2230057..2230722 + 666 WP_005184417.1 phage shock protein PspA -
OP861_RS10105 (OP861_10105) 2230864..2231091 + 228 WP_032906081.1 envelope stress response membrane protein PspB -
OP861_RS10110 (OP861_10110) 2231091..2231465 + 375 WP_050085264.1 envelope stress response membrane protein PspC -
OP861_RS10115 (OP861_10115) 2231574..2231813 + 240 WP_050085265.1 phage shock protein PspD -
OP861_RS10120 (OP861_10120) 2231794..2233191 + 1398 WP_032906079.1 YcjX family protein -
OP861_RS10125 (OP861_10125) 2233188..2234249 + 1062 WP_241916419.1 YcjF family protein -
OP861_RS10130 (OP861_10130) 2234275..2234733 - 459 WP_050085270.1 RES family NAD+ phosphorylase Toxin
OP861_RS10135 (OP861_10135) 2234819..2235265 - 447 WP_005184401.1 DUF2384 domain-containing protein Antitoxin
OP861_RS10140 (OP861_10140) 2235583..2237160 + 1578 WP_042569805.1 transcriptional regulator TyrR -
OP861_RS10145 (OP861_10145) 2237273..2237776 - 504 WP_050085272.1 thiol peroxidase -
OP861_RS10150 (OP861_10150) 2237930..2238901 + 972 WP_050085273.1 L-Ala-D/L-Glu epimerase -
OP861_RS10155 (OP861_10155) 2238898..2239605 - 708 WP_265535839.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-146)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17219.67 Da        Isoelectric Point: 4.8938

>T264238 WP_050085270.1 NZ_CP110789:c2234733-2234275 [Yersinia intermedia]
MMFYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMLLQPQ
DWPLDWRNDPAPAATMDIGTEWLESESSIGLLVPSTLVPSEHNMLVNPRHKDFQACLSTAKALAFAFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16256.70 Da        Isoelectric Point: 9.1234

>AT264238 WP_005184401.1 NZ_CP110789:c2235265-2234819 [Yersinia intermedia]
MRAYQPTPTTKAGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIVWMSTPIKGLGHRSPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A209A434

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M4Z0

References