Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 389513..391142 Replicon chromosome
Accession NZ_CP110789
Organism Yersinia intermedia strain SCPM-O-B-10209 (333)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OP861_RS01660 Protein ID WP_226717752.1
Coordinates 389513..390841 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OP861_RS01665 Protein ID WP_050312664.1
Coordinates 390843..391142 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP861_RS01645 (OP861_01645) 384936..385289 + 354 WP_032907677.1 MmcQ/YjbR family DNA-binding protein -
OP861_RS01650 (OP861_01650) 385429..388260 - 2832 WP_005191457.1 excinuclease ABC subunit UvrA -
OP861_RS01655 (OP861_01655) 388661..389209 + 549 WP_005191456.1 single-stranded DNA-binding protein SSB1 -
OP861_RS01660 (OP861_01660) 389513..390841 - 1329 WP_226717752.1 type II toxin-antitoxin system HipA family toxin Toxin
OP861_RS01665 (OP861_01665) 390843..391142 - 300 WP_050312664.1 helix-turn-helix transcriptional regulator Antitoxin
OP861_RS01670 (OP861_01670) 391412..392080 + 669 WP_005191448.1 glutathione S-transferase -
OP861_RS01675 (OP861_01675) 392556..393923 + 1368 WP_005191447.1 NCS2 family permease -
OP861_RS01680 (OP861_01680) 394141..395790 + 1650 WP_005191446.1 Na+/H+ antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50213.16 Da        Isoelectric Point: 7.2905

>T264230 WP_226717752.1 NZ_CP110789:c390841-389513 [Yersinia intermedia]
MTRRIKRLNIWMNGQYVGYWEKTRGEESLVYAQEWIENAQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATRYHADSINPFDLLFELGRDCVGAIQLLANDTPPADLFSIQQQPLTEHDVARILRNSWSDNTFVRPEHNEDLRLSIAGA
QEKTALLFHDDRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVARSEIGQFEDQKALIVERF
DRRLSRDNRWIVRLPQEDMCQASGTSPLKKYQIDGGPSMTTIMGILSGSDNASEDRNLFFKTQIIFWLLAATDGHAKNFS
IAHLPRNSYHLTPLYDVLSTHPIIGSSHNQIAIQKAKLAMAVRGSKNYYLINQIQRRHWRKQAELVGLGAYLADSIIDEV
ITATPRVIAQIQAQLPANFPTDLAESILTGLHRQCDKIAAMS

Download         Length: 1329 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11284.08 Da        Isoelectric Point: 8.9297

>AT264230 WP_050312664.1 NZ_CP110789:c391142-390843 [Yersinia intermedia]
MDYPIKILSQLRPTLIGFRKQKGLTQASLAQLLGITQQSYAKLEADPASASIERLFKVLQLLDVELILCEKKNVRLYSSK
THQPEESQTLNLPSKQEDW

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References