Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 52884..53527 Replicon chromosome
Accession NZ_CP110789
Organism Yersinia intermedia strain SCPM-O-B-10209 (333)

Toxin (Protein)


Gene name vagD Uniprot ID A0A209A7J6
Locus tag OP861_RS00230 Protein ID WP_050086921.1
Coordinates 53108..53527 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag OP861_RS00225 Protein ID WP_050136162.1
Coordinates 52884..53111 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP861_RS00200 (OP861_00200) 48105..49268 + 1164 WP_050086925.1 mannitol-1-phosphate 5-dehydrogenase -
OP861_RS00205 (OP861_00205) 49445..49999 + 555 WP_005186837.1 MltR family transcriptional regulator -
OP861_RS00210 (OP861_00210) 50001..50609 - 609 WP_032906751.1 LysE family translocator -
OP861_RS00215 (OP861_00215) 50825..52306 + 1482 WP_032906752.1 PLP-dependent aminotransferase family protein -
OP861_RS00220 (OP861_00220) 52399..52755 + 357 WP_005186841.1 YibL family ribosome-associated protein -
OP861_RS00225 (OP861_00225) 52884..53111 + 228 WP_050136162.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OP861_RS00230 (OP861_00230) 53108..53527 + 420 WP_050086921.1 type II toxin-antitoxin system VapC family toxin Toxin
OP861_RS00235 (OP861_00235) 53671..54342 - 672 WP_050086918.1 6-hydroxyaminopurine reductase -
OP861_RS00240 (OP861_00240) 54486..56447 - 1962 WP_265535602.1 methyl-accepting chemotaxis protein -
OP861_RS00245 (OP861_00245) 56842..57462 - 621 WP_265535603.1 superoxide dismutase [Mn] -
OP861_RS00250 (OP861_00250) 57587..58441 - 855 WP_050088620.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15588.20 Da        Isoelectric Point: 9.5042

>T264229 WP_050086921.1 NZ_CP110789:53108-53527 [Yersinia intermedia]
MMKRIYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILSWDA
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAISAGAILVTNNIREFERVKKLRIEDWSK

Download         Length: 420 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8740.93 Da        Isoelectric Point: 4.3533

>AT264229 WP_050136162.1 NZ_CP110789:52884-53111 [Yersinia intermedia]
MRTVSIFKNGQNRAIRLPKDMDFAGVTELEILKDGDNIILRPIRPTWVSFMDEDKADNDFLAERQDVIEEGRFEL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A209A7J6

Antitoxin

Source ID Structure

References